Dr Lisa Ivy Pilkington
2009 BA/BSc Conjoint (majoring in Chemistry, Statistics and German, University of Auckland, NZ)
2010 BSc(Hons, First Class; Chemistry, University of Auckland, NZ)
2014 PhD (Chemistry, University of Auckland, NZ)
2016 MSc (Statistics, University of Oxford, UK)
2014-2015 Post-Doctoral Research Fellow (ACSRC and School of Chemical Sciences, University of Auckland, NZ). Supervised by Assoc. Prof David Barker and Dr Euphemia Leung.
2016-2017 Post-Doctoral Research Fellow (School of Chemical Sciences, University of Auckland, NZ). Supervised by Dr Bruno Fedrizzi and Assoc. Prof David Barker.
2017-current Post-Doctoral Research Fellow (School of Chemical Sciences, University of Auckland, NZ). Supervised by Assoc. Prof David Barker.
Research | Current
My research focuses on the synthesis of organic molecules for a number of purposes including assessing their role as potential therapeutic agents and in biological processes. This involves the adaptation of existing and creation of new synthetic methods to achieve the preparation of novel compound structures.
Past and present projects include:
- The synthesis and investigation of novel, selective inhibitors of the CYP1 family of enzymes as anticancer agents.
- The synthesis of novel inhibitors of the PC-PLC enzyme and study of their efficacy as antiproliferative agents against human cancer.
- The synthesis of polysulfide compounds to explore their role in biological processes, particularly in cell-signalling.
- The synthesis of bioactive thieno-pyridines and pyrroloquinolines - compounds that have been shown to inhibit a number of important enzymes involved in cell regulation and are being analysed for their antiproliferative activity.
- The asymmetric synthesis of 1,4-benzodioxane lignans - biologically active compounds that exhibit a range of activites including cytotoxicity and hepaprotective properties.
Further areas of reserach include the adaptation of statistics to organic and analytical chemistry, including:
- Utilisation of statistical methods to explore the underlying differences and effects of various factors on an array of biological matrices.
- The investigation into the statistical modelling of the biological activities of ligands.
Teaching | Current
2017 - Lottery Health Research Post-Doctoral Fellowship
2016 - L H Briggs Memorial Prize for Best Doctoral Thesis (Chemistry, University of Auckland)
2015 - Gavin and Anne Kellaway Medical Research Fellowship
2015 - New Zealand Federation of Graduate Women Fellowship
2015 - Dean's List for Excellence (University of Auckland)
2011-2014 - University of Auckland Doctoral Scholar
2010 - University of Auckland Honours Scholarship
2009 - Statistic New Zealand Prize
2009 - Senior Prize in Statistics
2008,2009 - Faculty of Science Summer Scholarship
2008,2009 - Grace Kay Award
Language Editor (Biocatalysis)
Faculty of Science Post Doctoral Society (Secretary, Chemistry Department Rep.)
Selected publications and creative works (Research Outputs)
- Zafar, A., Pilkington, L. I., Haverkate, N. A., van Rensburg, M., Leung, E., Kumara, S., ... Hoskins, C. (2018). Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents. Molecules (Basel, Switzerland), 23 (1).10.3390/molecules23010145
Other University of Auckland co-authors: Johannes Reynisson, Ayesha Zafar, Natalie Haverkate, David Barker, Bill Denny, Euphemia Leung, Sisira Kumara, Michelle Van Rensburg
- Duhamel, N., Slaghenaufi, D., Pilkington, L. I., Herbst-Johnstone, M., Larcher, R., Barker, D., & Fedrizzi, B. (2018). Facile gas chromatography-tandem mass spectrometry stable isotope dilution method for the quantification of sesquiterpenes in grape. Journal of Chromatography A10.1016/j.chroma.2017.12.065
Other University of Auckland co-authors: David Barker
- Damavandi, M., Pilkington, L. I., Whitehead, K. A., Wilson-Nieuwenhuis, J., McBrearty, J., Dempsey-Hibbert, N., ... Barker, D. (2018). Poly(para-phenylene ethynylene) (PPE)- and poly(para-phenylene vinylene) (PPV)-poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride] (PMETAC) graft copolymers exhibit selective antimicrobial activity. European Polymer Journal, 98, 368-374. 10.1016/j.eurpolymj.2017.11.044
Other University of Auckland co-authors: David Barker
- Zafar, A., Sari, S., Leung, E., Pilkington, L. I., van Rensburg, M., Barker, D., & Reynisson, J. (2017). GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents. Molecules (Basel, Switzerland), 22 (12).10.3390/molecules22122254
Other University of Auckland co-authors: Johannes Reynisson, Ayesha Zafar, Euphemia Leung, David Barker, Michelle Van Rensburg
- Binsaleh, N. K., Wigley, C. A., Whitehead, K. A., van Rensburg, M., Reynisson, J., Pilkington, L. I., ... Dempsey-Hibbert, N. C. (2017). Thieno[2,3- b ]pyridine derivatives are potent anti-platelet drugs, inhibiting platelet activation, aggregation and showing synergy with aspirin. European Journal of Medicinal Chemistry10.1016/j.ejmech.2017.11.014
Other University of Auckland co-authors: Johannes Reynisson, David Barker
- Twidle, A. M., Suckling, D. M., Seal, A. G., Fedrizzi, B., Pilkington, L. I., & Barker, D. (2017). Identification of in situ flower volatiles from kiwifruit (Actinidia chinensis var. deliciosa) cultivars and their male pollenisers in a New Zealand orchard. Phytochemistry, 141, 61-69. 10.1016/j.phytochem.2017.05.011
Other University of Auckland co-authors: David Barker, Andrew Twidle, Bruno Fedrizzi, Max Suckling
- Pilkington, L., Song, S., Fedrizzi, B., & Barker, D. (2017). Efficient Total Synthesis of (±)-Isoguaiacin and (±)-Isogalbulin. Synlett, 28 (12), 1449-1452. 10.1055/s-0036-1588788
Other University of Auckland co-authors: Bruno Fedrizzi, David Barker
- Damavandi, M., Baek, P., Pilkington, L. I., Javed Chaudhary, O., Burn, P., Travas-Sejdic, J., & Barker, D. (2017). Synthesis of grafted poly( p- phenyleneethynylene) via ARGET ATRP: Towards nonaggregating and photoluminescence materials. European Polymer Journal, 89, 263-271. 10.1016/j.eurpolymj.2017.02.035
Other University of Auckland co-authors: David Barker, Jadranka Travas-Sejdic