Dr Elizabeth Joyce McKenzie

PhD (University of Auckland)

Biography

Liz did her Masters on the biogeochemistry of hot springs and her PhD on clandestine methamphetamine laboratories. Following her Masters, she worked in the Life in Extreme Environments program at at Portland State University,USA, then returned to New Zealand to work for Forensic & Industrial Science Ltd until 2013. While finishing her PhD in 2013, she worked at the Centre for Genomics, Proteomics and Metabolomics, School of Biological Sciences, University of Auckland. In 2015 she began a postdoctoral fellowship at the Liggins Institute where she worked on isolating biomarkers associated with complications of pregnancy.

Research | Current

Liz's research interests lie in the use of volatile biomarkers as diagnostic and investigative tools (volatilomics), where she applies gas chromatography-mass spectrometry (GC-MS) coupled with solid phase microextraction/thermal desorption to study milk, plasma/serum, faeces, skin and urine. Currently she is investigating the role of symbiotic fungi in the metabolism of short-chain fatty acids in the human gut, using SPME GC-MS and imaging mass spectrometry (MALDI-ToF-MS). She also has an interest in optimisation of untargeted data extraction and curation pipelines for mass spectrometry-based metabolomics and in developing statistical methods for detection of subtle metabolite dysregulation.

Teaching | Current

2016 - 2018 BioSci 741: Applied Microbiology & Biotechnology - Gut Metabolomics.

Postgraduate supervision

PhD students

  • Githal Arachchige - Liposoluble Vitamers (current)
  • Jamie De Seymour, graduated 2018  - Dietary patterns and biomarkers of gestational diabetes (Co-supervisor)
  • Melinda Thomas, graduated 2018 - Biomarkers of preterm birth (Co-supervisor)

MSc students

  • Magda Rosin - Human gut fungi and yeast (current)
  • Sachin Jayan, graduated 2017 - Faecal volatilome of children born preterm (Co-supervisor)

Summer students

  • Jena Macapagal - LC-MS method for metabolomic analysis of plasma samples (2015/16)
  • Kieran Deane-Alder - JGL Network Analysis in Metabolomics (2016/17)
  • Nita McKenzie - SkinOmics (2017/18)
  • Tuan Tuan Cheng - LDGM Network Analysis in Metabolomics (2017/18)

Responsibilities

Co-oversight of of Mass Spectrometry Hub Strategic Research Initiative (with Dr Frederik Pruijn and SRIF lead PI Dr Angus Grey), coordinate Virtual Machine implementation and software evaluation and acquisition, metabolomics data platform implementation.

Areas of expertise

Chemical contamination in former clandestine methamphetamine laboratories

Gas Chromatography-Mass Spectrometry

Solid Phase MicroExtraction

Committees/Professional groups/Services

2017 - current. University of Auckland Mass Spectrometry Hub SRIF ($600K) Co-oversight and MS Data lead
2017 - 2019     Australia & NZ Society for Mass Spectrometry Conference organising committee
2015 - current. Health & Safety Committee, Liggins Institute
2013 - current. Founder and co-facilitator, Chrom Mass Spec Tech Support list-serv (80 members)
2013 - 2015     Health & Safety Committee, School of Biological Sciences
2005 - 2007     Independent Forensic Practitioners Institute, founding member and exec committee member

Selected publications and creative works (Research Outputs)

  • Y de Vries, J., Pundir, S., Mckenzie, E., Keijer, J., & Kussmann, M. (2018). Maternal Circulating Vitamin Status and Colostrum Vitamin Composition in Healthy Lactating Women-A Systematic Approach. Nutrients, 10 (6).10.3390/nu10060687
    URL: http://hdl.handle.net/2292/45847
    Other University of Auckland co-authors: Shikha Pundir
  • Jones, B., Han, T.-L., Delplancke, T., McKenzie, E. J., de Seymour, J. V., Chua, M. C., ... Baker, P. N. (2018). Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis. Scientific reports, 8 (1)10.1038/s41598-018-24936-5
    URL: http://hdl.handle.net/2292/43532
    Other University of Auckland co-authors: Beatrix Jones
  • de Seymour, J., Chia, A., Colega, M., Jones, B., McKenzie, E., Shirong, C., ... Conlon, C. (2016). Maternal Dietary Patterns and Gestational Diabetes Mellitus in a Multi-Ethnic Asian Cohort: The GUSTO Study. Nutrients, 8 (9), 1-12. 10.3390/nu8090574
    URL: http://hdl.handle.net/2292/30949
    Other University of Auckland co-authors: Beatrix Jones
  • Thomas, M. M., Sulek, K., McKenzie, E. J., Jones, B., Han, T. L., Villas-Boas, S. G., ... Baker, P. N. (2015). Metabolite profile of cervicovaginal fluids from early pregnancy is not predictive of spontaneous preterm birth. International journal of molecular sciences, 16 (11), 27741-27748. 10.3390/ijms161126052
    URL: http://hdl.handle.net/2292/32430
    Other University of Auckland co-authors: Silas Villas-Boas, Lesley McCowan, Beatrix Jones
  • McKenzie, E. J. (2014). Chemical contamination in former clandestine methamphetamine laboratories The University of Auckland. ResearchSpace@Auckland.
    URL: http://hdl.handle.net/2292/22473
  • McKenzie, E. J., Miskelly, G. M., & Butler, P. A. G. (2013). Detection of methamphetamine in indoor air using dynamic solid phase microextraction: A supplementary method to surface wipe sampling. Analytical Methods, 5 (20), 5418-5424. 10.1039/c3ay40537k
    Other University of Auckland co-authors: Gordon Miskelly
  • McKenzie, E. J., Miskelly, G. M., & Butler, P. A. G. (2013). Dynamic solid phase microextraction analysis for airborne methamphetamine: Quantitation using isotopically substituted methamphetamine. Analytical Methods, 5 (17), 4391-4396. 10.1039/c3ay40536b
    Other University of Auckland co-authors: Gordon Miskelly
  • McKenzie, E. J., Brown, K. L., Cady, S. L., & Campbell, K. A. (2001). Trace metal chemistry and silicification of microorganisms in geothermal sinter, Taupo volcanic zone, New Zealand. Geothermics, 30 (4), 483-502. 10.1016/S0375-6505(01)00004-9
    URL: http://hdl.handle.net/2292/23413
    Other University of Auckland co-authors: Kathleen Campbell

Identifiers

Contact details

Primary office location

M&HS BUILDING 502 - Bldg 502
Level 4, Room 420
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links