Dr Matthew Bull

BSc MSc PhD Auck.

Biography

Postdoctoral research fellow at the Auckland Cancer Society Research Centre with the Translational Therapeutics Team, led by Associate Professor Adam Patterson.

Research | Current

  • Ongoing development of TH-4000, a hypoxia-selective tyrosine kinase inhibitor (TKI) curently in Phase 2 clincial trials for lung cancer and Head/Neck cancer in USA and Australia
  • Development of additional hypoxia-selective TKI prodrugs
  • Development of the hypoxia-selective analogues of the prodrug PR-104

Areas of expertise

  • Pharmacokinetics
  • In vitro metabolism
  • Bioanalysis (HPLC, LC/MS/MS, SPR etc)
  • Hypoxia activated prodrugs
  • Cancer drug development

Selected publications and creative works (Research Outputs)

  • Spicer, J. A., Miller, C. K., O'Connor PD, Jose, J., Giddens, A. C., Jaiswal, J. K., ... Akhlaghi, H. (2020). Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo. Journal of medicinal chemistry, 63 (5), 2229-2239. 10.1021/acs.jmedchem.9b00881
    Other University of Auckland co-authors: Bill Denny, Julie Spicer, Christian Miller, Jiney Jose, Stephen Jamieson, Jagdish Jaiswal
  • Mowday, A., Ashoorzadeh, A., Williams, E., Copp, J., Silva, S., Bull, M., ... Guise, C. (2016). Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy. Biochemical Pharmacology, 116, 176-187. 10.1016/j.bcp.2016.07.015
    URL: http://hdl.handle.net/2292/30209
    Other University of Auckland co-authors: Jack Flanagan, Adam Patterson, Bob Anderson, Jeff Smaill, Amir Ashoorzadeh
  • Silva, S., Jackson, V., Guise, C., Abbattista, M., Bull, M., Grey, A., ... Pearce, T. (2015). Preclinical efficacy of tarloxotinib bromide (TH­4000), a hypoxia­activated EGFR/HER2 inhibitor: Rationale for clinical evaluation in EGFR mutant, T790M-­negative NSCLC following progression on EGFRTKI therapy. Paper presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, Massachusetts. 5 November - 9 November 2015. Molecular Cancer Therapeutics. (pp. 2).
    Other University of Auckland co-authors: Gus Grey, Bob Anderson, Amir Ashoorzadeh, Adam Patterson, Jeff Smaill, Victoria Jackson-Patel
  • Bull, M., Spicer, J., Huttunen, K., Denny, W., Ciccone, A., Browne, K., ... Helsby, N. (2015). The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents. European Journal of Drug Metabolism and Pharmacokinetics, 40 (4), 417-425. 10.1007/s13318-014-0220-y
    URL: http://hdl.handle.net/2292/32537
    Other University of Auckland co-authors: Bill Denny, Julie Spicer, Nuala Helsby
  • Patterson, A., Silva, S., Jackson, V., Guise, C., Abbattista, M. R., Bull, M., ... Jung, D. (2015). The hypoxia-activated EGFR-TKI TH-4000: Preclinical profile and ongoing clinical studies in NSCLC, SCCHN, and SCCS. Paper presented at 14th International Tumor Microenvironment Workshop: Hypoxia, Angiogensis and Vasculature, Vancouver, Canada. 27 August - 29 August 2015.
    URL: http://hdl.handle.net/2292/27747
    Other University of Auckland co-authors: Adam Patterson, Amir Ashoorzadeh, Bob Anderson, Jeff Smaill, Gus Grey
  • Patterson, A. V., Silva, S., Guise, C., Abbattista, M., Bull, M., Hsu, H.-L., ... Ashoorzadeh, A. (2015). The hypoxia-activated EGFR-TKI TH-4000 overcomes erlotinib-resistance in preclinical NSCLC models at plasma levels achieved in a Phase 1 clinical trial. Paper presented at 106th Annual Meeting of the American Association for Cancer Research (AACR), Philadelphia, Pennsylvania, USA. 18 April - 22 April 2015. Cancer Research. (pp. 2). 10.1158/1538-7445.AM2015-5358
    Other University of Auckland co-authors: Gus Grey, Adam Patterson, Amir Ashoorzadeh, Bob Anderson, Jeff Smaill
  • Patterson, A. V., Silva, S., Guise, C., Bull, M., Abbattista, M., Hsu, A., ... Smaill, J. B. (2015). TH-4000, a hypoxia-activated EGFR/Her2 inhibitor to treat EGFR-TKI resistant T790M-negative NSCLC. Paper presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Clinical Science Symposium on Predicting and Improving Adverse Outcomes in Older Adults with Cancer, Chicago, Illinois, USA. 29 May - 2 June 2015. Journal of Clinical Oncology. (pp. 1).
    Other University of Auckland co-authors: Jeff Smaill, Adam Patterson
  • Spicer, J., Lena, G., Lyons, D., Huttunen, K., Miller, C., O'Connor P, ... Denny, W. (2013). Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. Journal of Medicinal Chemistry, 56 (23), 9542-9555. 10.1021/jm401604x
    URL: http://hdl.handle.net/2292/34207
    Other University of Auckland co-authors: Nuala Helsby, Christian Miller, Bill Denny, Julie Spicer, Stephen Jamieson

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 0, Room 005
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

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