Professor Michael Dragunow

BSc, DipSci, MSc, Phd, FRSNZ

Research | Current

I am a Molecular Pharmacologist and Neuroscientist. My research focuses on molecular mechanisms of human brain neurodegeneration and repair and on developing novel treatments for brain diseases using adult human brain material, tissue microarray, cell culture models (cell lines and primary adult human brain cultures), molecular pharmacology and high-content analysis. These combined research tools are being used to understand the causes of human neurodegeneration and to test and develop new treatment strategies.

Postgraduate supervision

PhD students (Main Supervisor)


PhD students (Co-supervisor)

Selected publications and creative works (Research Outputs)

  • Coppieters, N., Dieriks, B. V., Lill, C., Faull, R. L. M., Curtis, M. A., & Dragunow, M. (2014). Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain. Neurobiol Aging, 35 (6), 1334-1344. 10.1016/j.neurobiolaging.2013.11.031
    Other University of Auckland co-authors: Maurice Curtis, Richard Faull, Victor Dieriks, Natacha Coppieters 't Wallant
  • Smith, A. M., & Dragunow, M. (2014). The human side of microglia. Trends Neurosci, 37 (3), 125-135. 10.1016/j.tins.2013.12.001
  • Vance, C., Scotter, E. L., Nishimura, A. L., Troakes, C., Mitchell, J. C., Kathe, C., ... Hortobágyi T (2013). ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules. Human Molecular Genetics, 22 (13), 2676-2688. 10.1093/hmg/ddt117
    URL: http://hdl.handle.net/2292/23483
    Other University of Auckland co-authors: Emma Scotter
  • Smith, A. M., Gibbons, H. M., Oldfield, R. L., Bergin, P. M., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2013). The transcription factor PU.1 is critical for viability and function of human brain microglia. GLIA, 61 (6), 929-942. 10.1002/glia.22486
    Other University of Auckland co-authors: Richard Faull
  • Dragunow, M. (2013). Meningeal and choroid plexus cells--novel drug targets for CNS disorders. Brain Res, 1501, 32-55. 10.1016/j.brainres.2013.01.013
  • Gibbons, H. M., Smith, A. M., Teoh, H. H., Bergin, P. M., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2011). Valproic acid induces microglial dysfunction, not apoptosis, in human glial cultures. Neurobiology of Disease, 41 (1), 96-103. 10.1016/j.nbd.2010.08.024
    URL: http://hdl.handle.net/2292/15648
    Other University of Auckland co-authors: Richard Faull
  • Dragunow, M. (2008). Opinion - High-content analysis in neuroscience. NATURE REVIEWS NEUROSCIENCE, 9 (10), 779-788. 10.1038/nrn2492
  • Dragunow, M. (2008). Opinion - The adult human brain in preclinical drug development. NATURE REVIEWS DRUG DISCOVERY, 7 (8), 659-U10. 10.1038/nrd2617

Contact details

Primary location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 501G
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand