Dr Muhammad Hanif

Dr. rer. nat. (PhD, 2010) from the University of Vienna, Austria

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Research Fellow

Biography

2015-present, Research Fellow, the University of Auckland (New Zealand

2013–2015, Erwin Schrödinger Fellow, University of Auckland (New Zealand)

2011-2013, Assistant Professor, COMSATS University Islamabad (Pakistan)

2007-2010, Research Assistant, University of Vienna (Austria)

Research | Current

My research interests are in synthetic inorganic chemistry at the interface with biology and medicine. The particular focus is on the design and development of metal complexes as anticancer agents and for catalysis in cells. These projects encompass a variety of metal ions as well as numerous carefully designed ligand systems. Moreover, a vast panoply of biophysical techniques and cellular analyses is used for a thorough understanding of their reactivity and modes of action.

Teaching | Current

TFC CHEM 91F Foundation Chemistry 1 - Semester One 2019

CHEM 735 Advanced Medicinal Chemistry - Semester One 2019

 

Distinctions/Honours

2012 Erwin Schrödinger Fellowship of the Austrian Science Fund

2010 Distinction in PhD

 

Areas of expertise

Medicinal Bioinorganic Chemistry, Coordination Chemistry, Synthetic Inorganic Chemistry and Organometallic Chemistry

Committees/Professional groups/Services

  • Member – Royal Society of Chemistry UK
  • Member  – Society of Biological Inorganic Chemistry
  • Member – New Zealand Institute of Chemistry
  • Affiliate Investigator Maurice Wilkins Centre

Selected publications and creative works (Research Outputs)

  • Movassaghi, S., Singh, S., Mansur, A., Tong, K. K. H., Hanif, M., Holtkamp, H. U., ... Hartinger, C. G. (2018). (Pyridin-2-yl)-NHC Organoruthenium Complexes: Antiproliferative Properties and Reactivity Toward Biomolecules (vol 37, pg 1575, 2018). ORGANOMETALLICS, 37 (21), 4172-4172. 10.1021/acs.organomet.8b00706
    Other University of Auckland co-authors: Christian Hartinger, Stephen Jamieson
  • Arshad, J., Hanif, M., Zafar, A., Movassaghi, S., Tong, K. K. H., Reynisson, J., ... Jamieson, S. M. F. (2018). Organoruthenium and Organoosmium Complexes of 2-Pyridinecarbothioamides Functionalized with a Sulfonamide Motif: Synthesis, Cytotoxicity and Biomolecule Interactions. ChemPlusChem, 83 (7), 612-619. 10.1002/cplu.201800194
    Other University of Auckland co-authors: Ayesha Zafar, Stephen Jamieson, Christian Hartinger, Tilo Söhnel, Kelvin Tong
  • Movassaghi, S., Leung, E., Hanif, M., Lee, B. Y. T., Holtkamp, H. U., Tu, J. K. Y., ... Hartinger, C. G. (2018). A Bioactive l-Phenylalanine-Derived Arene in Multitargeted Organoruthenium Compounds: Impact on the Antiproliferative Activity and Mode of Action. Inorganic chemistry, 57 (14), 8521-8529. 10.1021/acs.inorgchem.8b01187
    Other University of Auckland co-authors: Christian Hartinger, Euphemia Leung, Stephen Jamieson, Betty Lee
  • Movassaghi, S., Singh, S., Mansur, A., Tong, K. K. H., Hanif, M., Holtkamp, H. U., ... Hartinger, C. G. (2018). (Pyridin-2-yl)-NHC Organoruthenium Complexes: Antiproliferative Properties and Reactivity toward Biomolecules. Organometallics, 37 (10), 1575-1584. 10.1021/acs.organomet.8b00153
    Other University of Auckland co-authors: Christian Hartinger, Stephen Jamieson, Kelvin Tong
  • Hanif, M., & Hartinger, C. G. (2018). Anticancer metallodrugs: where is the next cisplatin?. Future medicinal chemistry, 10 (6), 615-617. 10.4155/fmc-2017-0317
    Other University of Auckland co-authors: Christian Hartinger
  • Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., ... Jakupec, M. A. (2018). Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic chemistry, 57 (5), 2851-2864. 10.1021/acs.inorgchem.7b03210
    Other University of Auckland co-authors: Christian Hartinger
  • Movassaghi, S., Hanif, M., Holtkamp, H. U., Söhnel T, Jamieson, S. M. F., & Hartinger, C. G. (2018). Making organoruthenium complexes of 8-hydroxyquinolines more hydrophilic: impact of a novel l-phenylalanine-derived arene ligand on the biological activity. Dalton transactions (Cambridge, England : 2003), 47 (7), 2192-2201. 10.1039/c7dt04451h
    Other University of Auckland co-authors: Christian Hartinger, Tilo Söhnel, Stephen Jamieson
  • Hanif, M., & Hartinger, C. G. (2018). Ruthenium anticancer agents en route to the tumor: From plasma protein binding agents to targeted delivery. In A. A. Holder, L. Lilge, W. R. Browne, M. A. Lawrence, J. L. Bullock (Eds.) Ruthenium Complexes Photochemical and Biomedical Applications (pp. 161-180). Weinheim: Wiley-VCH. 10.1002/9783527695225.ch8
    Other University of Auckland co-authors: Christian Hartinger

Contact details

Primary office location

SCIENCE CENTRE 302 - Bldg 302
Level 10, Room 1033
23 SYMONDS ST
AUCKLAND CENTRAL
AUCKLAND 1010
New Zealand

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