Dr Maggie Lucy Kalev-Zylinska
MBChB, PhD, FRCPA
I am a medical academic trained in New Zealand (since 1995), South Africa (1991-1994) and Poland (prior to 1991). My medical specialty is in Laboratory Haematology with a Fellowship of the Royal College of Pathologists of Australasia gained in 2000. I first joined the University of Auckland (UoA) in 1999 when I undertook a PhD into the mechanisms of leukaemogenesis, completing it in 2003. I then continued in a post-doctoral position until 2008 learning genetic modification and gene therapy approaches. In 2009, I was appointed to a position of Senior Lecturer in Cancer Biology and returned to haematological science. My current UoA position includes 0.2 FTE as Consultant Haematologist at LabPlus, Auckland District Health Board, where my expertise is in haematological cancer diagnosis. Since my appointment at the UoA in 2009, I have established and now lead an independent research group that focuses on blood and cancer biology.
- 2003 PhD in Molecular Medicine, University of Auckland
- 2000 FRCPA in Haematology, Royal College of Pathologists of Australasia
- 1990 MBChB Medicine and Surgery, Pomeranian Medical School (Pomorska Akademia Medyczna), Szczecin, Poland
Professional positions held:
- 2009-present Senior Lecturer, Department of Molecular Medicine and Pathology, University of Auckland (0.8 FTE)
- 2005-present Consultant Haematologist, LabPlus Haematology, Auckland District Health Board (0.2 FTE)
- 2000-2008 Consultant Haematologist, casual sessions, Diagnostic MedLab, Auckland
- 2004-2008 Research Fellow, Functional Genomics and Translational Neuroscience Laboratory, University of Auckland
- 1999-2003 PhD Fellowship, Developmental Genetics and Leukaemia Laboratory, University of Auckland
- 1996-1998 Registrar in Haematology, Auckland City and Middlemore Hospitals, New Zealand Blood Service
- 1993-1994 Registrar in Haematology (Haematology Laboratory, Bone Marrow Transplant Unit, Haematology Ward and Outpatients), Groote Schuur Hospital, Cape Town, South Africa
- 1991-1994 Senior House Officer in Haematology and Cardiology (Bone Marrow Transplant Unit, Haematology Outpatients, Intensive Coronary Care Unit and Haematology Laboratory), Groote Schuur Hospital, Cape Town, South Africa
- 1990-1991 Resident in Cardiology, Intensive Care Unit, Collegium Medicum of the Jagiellonian University, Cracow, Poland
- 1989-1990 Intern, Military Hospital, Cracow, Poland
Research | Current
Research group: Bone, Joint, Cancer and Reproduction Cluster - Kalev group
- Laboratory and molecular haematology
- Leukaemia and cancer biology
- Bone marrow niche and haematopoietic stem cells
- Megakaryocytes and platelets
- Calcium signalling
- Experimental therapeutic targets
- Gene editing
Research funding - since appointment in 2009:
Total number of research grants as PI or AI: 15
- External Research Grants:
- 10 totalling $1,049,653 as PI
- 1 of $31,727 as AI
- 2 totalling $2,063,556 as Named Investigator
- Internal Research Grants:
- 3 totalling $97,000 as PI
- 1 of $149,800 as AI
Total grants as PI or AI: $1,328,180
Grant details as PI - since 2009
2016-2018 Auckland Medical Research Foundation; project grant: Calcium balance in megakaryocytes; $144,945
2016-2018 Genesis Oncology Trust; project grant: Biology of megakaryocytic cancers; $50,000
2016-2018 Leukaemia & Blood Cancer NZ; project grant: New tools to study megakaryocytic cancers; $48,000
2013-2014 Lottery Health Research; equipment grant: Mindray BC5300 haematology analyser; $44,000
2012-2015 Child Cancer Foundation; project grant: NMDA receptors in megakaryoblastic leukaemia; $155,847
Funding from donation by Anne and David Norman and Family towards PhD fellowships for students together with the contribution towards their working expenses
2011-2014 Cancer Society; small project grant: NMDA receptors in melanoma; $15,000
2010-2013 Royal Society of New Zealand, Marsden Fast Start; project grant: Human antiplatelet autoantibodies; $300,000
2010-2011 Manchester Trust, School of Medicine Foundation; project grant: Glutamate signalling in acute megakaryoblastic leukaemia; $55,000
2010-2012 Freemasons NZ, School of Medicine Foundation; travelling fellowship: PJ Smith Fellowship; $22,000
2009-2012 Neurological Foundation; project grant: Anti NMDA-NR1 antibodies and damage from stroke; $131,861
Teaching | Current
- MedSci 302 Cancer Biology: Cancer Hallmarks, Cancer Epidemiology, Tumour Microenvironment, Tumour Invasion and Metastasis, Tumour Angiogenesis, Impact of Oncogenes and Tumour Suppressors on Cancer Development and Progression - Clinical Examples, Integration of Morphology, Immunophenotyping and Genetics in Cancer Diagnosis and Research. Course Director.
- MedSci 713 Principles of Cancer Therapy: Haematopoietic Stem Cell Transplantation, Cellular Therapies, Modulation of Tumour Environment. Course Coordinator and Director.
- MedSci 714 Advanced Cancer Biology: Lymphoma Biology, Leukaemia Biology.
- Contributes to other MEDSCI and MBChB teaching from stage 2 to 5 (2000-2015).
- 2015-present James Hearn; main supervisor. Scholarship funded by the Leukaemia and Lymphoma PhD Fellowship from donation by Anne, Victoria and David Norman.
- 2015-present Sarvenaz Taghawi; co-supervisor
- 2012-2016 Tania Kamal; main supervisor. Scholarship funded by the Leukaemia and Lymphoma PhD Fellowship from donation by Anne, Victoria and David Norman and the Doctoral Scholarship by the University of Auckland. Completed.
- 2011-2016 Stacey D'mello; main supervisor. Scholarship funded by Auckland Medical Research Foundation. Completed.
- 2012-2016 Alexander Trevarton; advisor. Completed.
- 2010-2015 Thomas Chen; co-supervisor. Completed.
- 2015 Yohanes Nursalim; main supervisor. Completed - First Class.
- 2013 James Hearn; main supervisor. Completed - First Class.
- 2012 Young-Eun Park; main supervisor. Completed - First Class.
- 2012 Sugandha Chugh; main supervisor. Completed - Second Class.
- 2011 Peng (Paul) Sun; main supervisor. Completed - First Class.
- 2010 Thomas Chen; main supervisor. Completed - First Class.
- 2009 Srividya Arunachalam; main supervisor.
- 2006 Supinya Dejnoprat; main supervisor. Completed; First Class.
- 2005 Alexander Trevarton; main supervisor. Completed; First Class
- 2015 Filip Nikolic; main supervisor
- 2015 Alyona Oryshchuk; main supervisor.
- 2013 James Hearn; main supervisor
- 2012 Rushi Penumarthy; main supervisor.
- 2011 Caroline Kang; main supervisor.
- 2011 Rushi Penumarthy; main supervisor.
- 2008 Acrane Li; main supervisor.
- 2007 Vincent Chong; main supervisor. Report highly commended by the University of Auckland Judging Panel.
- 2007 Farrah Rodrigues; main supervisor.
- 2006 Isuru Dilshan; main supervisor.
- 2005 Kathryn Goldstone; main supervisor. Report highly commended by the University of Auckland Judging Panel.
- 2004 Alexander Trevarton; main supervisor.
- 2003 Anika Lam; main supervisor.
2012 selected into Women in Leadership Programme, University of Auckland
2010 PJ Smith New Zealand Freemasons Travelling Fellowship to the University of Sydney
2010 Visiting Research Fellow, University of Sydney, Australia
2009 McBeath Child Cancer Award, School of Medicine Foundation, University of Auckland
2009 selected into the Forum of Academic Leaders, University of Auckland
2003 Best Doctoral Thesis Award, University of Auckland
1999 Registrar in Research Award, Royal College of Pathologists of Australasia
1998 Ruth Spencer Medical Research Fellowship, Auckland Medical Research Foundation
1997 Neil Prentice Memorial Prize for the Top Candidate in Pathological Sciences Examination in Australasia
1989 Gold Medal: Best Medical Graduate, Pomeranian Medical School, Poland
1989 Scholarship of the Polish Foundation Talent-Promotion-Progress, Ministry of Health, Poland
- Leads an idepedent research group into blood and cancer biology
- Works as specialist haematologist at LabPlus, Auckland District Health Board
- Directs teaching into cancer biology and cancer therapy: MedSci 302 (Cancer Biology; 2009-present), MedSci 713 (Principles of Cancer Therapy; 2009-present) and MedSci 714 (Advanced Cancer Biology - 2009-2015)
- Teaches cancer biology, experimental cancer therapy and clinical haematology in MedSci and MBChB courses
Areas of expertise
- laboratory haematology
- molecular haematology
- leukaemia biology
- megakaryocytes and platelets
- cancer biology
- cancer research
- Faculty Research Development Fund Committee, School of Medical Sciences, Member, 2009-2012.
- Co-opted member of the Staff Advisory Committee for the School of Medical Sciences, 2013.
- HoD Nominee for 4 PhD theses examinations
- Examiner of 1 PhD and 3 masters theses (two for the University of Otago)
- Assessor of another 3 masters theses
- Ad hoc Departmental Graduate Advisor 2015
- DSAC advisor 2014
- Review of VJU transgenic services 2014
- Women in Leadership Programme , LabPlus, ADHB 2013
- Provisional PhD year Reviewer for the School of Pharmacy 2013
- Ad hoc referee for national funding agencies:
- • Cancer Society of New Zealand
- • Cure Kids
- • Maurice and Phyllis Paykel Trust
- Ad hoc referee for international journals:
- • PLOS One
- • Clinical Genetics
- • Scientific Reports
- • Internal Medicine Journal
I have gained Fellowship of the Royal College of Pathologists of Australasia in the specialty of Haematology in 2000. From 2000 to 2008 (during my PhD and post-doc), I worked evening sessions at the Diagnostic MedLab Community Laboratories, reviewing abnormal peripheral blood results, coagulation testing, haemoglobinopathy screens and immunophenotyping studies. My role was to interpret laboratory abnormalities to general practitioners, including advice on patient management. In 2005, I was appointed as Consultant Haematologist at LabPlus, Auckland District Health Board, initially on a temporary 0.2 FTE contract that became permanent in 2009 upon my appointment to Senior Lecturer at the UoA. My main role in the Haematology Laboratory is to diagnose disorders affecting bone marrow and peripheral blood, mostly haematological cancers but I also provide consultative haematology based on the pathology review of peripheral blood and bone marrow morphology abnormalities.
Main clinical competencies:
- Diagnosis of acute and chronic leukaemias based on the integrated analysis of morphology, immunophenotyping and genetics according to the current WHO criteria
- Bone marrow examination in the context of a wide range of haematological disease, from benign to malignant.
- Staging of lymphomas and solid tumours in children and adults
- General consultative haematology – in particular based on the analytic and morphology review of peripheral blood and bone marrow
Contributions to improve diagnostic service at LabPlus, ADHB:
- Ongoing efforts to establish a platform for patient participation in biological research.
- Established FISH methodology for routine diagnostic use at LabPlus Cytogenetics Laboratory. This work was performed together with Paul Oei and Daniel Ng, and with support from Dr Lochie Teague (Starship). 1999.
- Established an immunofluorescent PML Protein Localisation Assay at LabPlus Haematology to allow rapid diagnosis of Acute Promyelocytic Leukaemia (APML). This work was performed with mentorship from Prof Peter Browett and help by Jan Nelson. 1999.
2015 – present Member, New Zealand Laboratory Haematology Study Group
2012 – present Member, International Society on Thrombosis and Haemostasis (ISTH)
2010 – present Member, Australasian Society of Thrombosis and Haemostasis (ASTH)
2007 – present Member, American Society of Hematology (ASH)
2004 – 2009 Member, Society for Neuroscience (SFN)
1998 – present Member, Haematology Society of Australia and New Zealand (HSANZ)
Selected publications and creative works (Research Outputs)
- Green, T. N., Hamilton, J. R., Morel-Kopp, M.-C., Zheng, Z., Chen, T.-Y. T., Hearn, J. I., ... Barber, P. A. (2017). Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis. Platelets, 1-13. 10.1080/09537104.2017.1280149
Other University of Auckland co-authors: Jack Flanagan, Deborah Young, Alan Barber
- D’mello SAN, Joseph, W. R., Green, T. N., Leung, E. Y., During, M. J., Finlay, G. J., ... Kalev-Zylinska, M. L. (2016). Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate. Cell Calcium, 60 (6), 384-395. 10.1016/j.ceca.2016.09.003
Other University of Auckland co-authors: Graeme Finlay, Euphemia Leung, Bruce Baguley, Wayne Joseph
- Kamal, T., Green, T. N., Morel-Kopp, M.-C., Ward, C. M., McGregor, A. L., McGlashan, S. R., ... During, M. J. (2015). Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation. Cellular Signalling, 27 (9), 1860-1872. 10.1016/j.cellsig.2015.05.004
Other University of Auckland co-authors: Stefan Bohlander, Sue McGlashan, Ailsa McGregor, Peter Browett
- Kalev-Zylinska, M. L., Green, T. N., Morel-Kopp, M. C., Sun, P. P., Park, Y. E., Lasham, A., ... Ward, C. M. (2014). N-methyl-d-aspartate receptors amplify activation and aggregation of human platelets. Thrombosis Research, 133 (5), 837-847. 10.1016/j.thromres.2014.02.011
Other University of Auckland co-authors: Annette Lasham
- D'mello SAN, Flanagan, J. U., Green, T. N., Leung, E. Y., Askarian-Amiri, M. E., Joseph, W. R., ... Furneaux, C. E. (2014). Evidence that GRIN2A mutations in melanoma correlate with decreased survival. Frontiers in Oncology, 4 JAN.10.3389/fonc.2013.00333
Other University of Auckland co-authors: Euphemia Leung, Jack Flanagan, Wayne Joseph, Graeme Finlay, Bruce Baguley, Marjan Askarian Amiri
- Kalev-Zylinska, M. L., Symes, W., Little, K. C. E., Sun, P., Wen, D., Qiao, L., ... Barber, P. A. (2013). Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size. Stroke, 44 (8), 2212-2219. 10.1161/STROKEAHA.113.001235
Other University of Auckland co-authors: Alan Barber, Deborah Young
- Kalev-Zylinska, M. L., Symes, W., Young, D., & During, M. J. (2009). Knockdown and overexpression of NR1 modulates NMDA receptor function. MOLECULAR AND CELLULAR NEUROSCIENCE, 41 (4), 383-396. 10.1016/j.mcn.2009.04.003
Other University of Auckland co-authors: Deborah Young
- Lam, E. Y. N., Chau, J. Y. M., Kalev-Zylinska, M. L., Fountaine, T. M., Mead, R. S., Hall, C. J., ... Flores, M. V. (2009). Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors. BLOOD, 113 (6), 1241-1249. 10.1182/blood-2008-04-149898
Other University of Auckland co-authors: Christopher Hall
LabPlus Haematology, Auckland District Health Board
M&HS BUILDING 502 - Bldg 502
Level 2, Room 201F
85 PARK RD