Dr Maggie Lucy Kalev-Zylinska

MBChB, PhD, FRCPA

Biography

I am a medical academic trained in New Zealand (since 1995), South Africa (1991-1994) and Poland (prior to 1991). My medical specialty is in Laboratory Haematology with a Fellowship of the Royal College of Pathologists of Australasia gained in 2000. I first joined the University of Auckland (UoA) in 1999 when I undertook a PhD into the mechanisms of leukaemogenesis, completing it in 2003. I then continued in a post-doctoral position until 2008 learning genetic modification and gene therapy approaches. In 2009, I was appointed to a position of Senior Lecturer in Cancer Biology and returned to haematological science. My current UoA position includes 0.2 FTE as Consultant Haematologist at LabPlus, Auckland District Health Board, where my expertise is in haematological cancer diagnosis. Since my appointment at the UoA in 2009, I have established and now lead an independent research group that focuses on blood and cancer biology.

Academic qualifications:

  • 2003              PhD in Molecular Medicine, University of Auckland
  • 2000              FRCPA in Haematology, Royal College of Pathologists of Australasia
  • 1990              MBChB Medicine and Surgery, Pomeranian Medical School (Pomorska  Akademia Medyczna), Szczecin, Poland

Professional positions held:

  • 2009-present  Senior Lecturer, Department of Molecular Medicine and Pathology, University of Auckland (0.8 FTE)
  • 2005-present  Consultant Haematologist, LabPlus Haematology, Auckland District Health Board (0.2 FTE)
  • 2000-2008      Consultant Haematologist, casual sessions, Diagnostic MedLab, Auckland
  • 2004-2008      Research Fellow, Functional Genomics and Translational Neuroscience Laboratory, University of Auckland
  • 1999-2003      PhD Fellowship, Developmental Genetics and Leukaemia Laboratory, University of Auckland
  • 1996-1998      Registrar in Haematology, Auckland City and Middlemore Hospitals, New Zealand Blood Service
  • 1993-1994      Registrar in Haematology (Haematology Laboratory, Bone Marrow Transplant Unit, Haematology Ward and Outpatients), Groote Schuur Hospital, Cape Town, South Africa
  • 1991-1994      Senior House Officer in Haematology and Cardiology (Bone Marrow Transplant Unit, Haematology Outpatients, Intensive Coronary Care Unit and Haematology Laboratory), Groote Schuur Hospital, Cape Town, South Africa
  • 1990-1991     Resident in Cardiology, Intensive Care Unit, Collegium Medicum of the Jagiellonian University, Cracow, Poland
  • 1989-1990     Intern, Military Hospital, Cracow, Poland

Research | Current

Research group: Bone, Joint, Cancer and Reproduction Cluster - Kalev group

Research interests:

  • Laboratory and molecular haematology
  • Leukaemia and cancer biology
  • Bone marrow niche and haematopoietic stem cells
  • Megakaryocytes and platelets
  • Calcium signalling
  • Experimental therapeutic targets
  • Gene editing 

Research funding - since appointment in 2009:

Total number of research grants as PI or AI: 15

  • External Research Grants:
    • 10 totalling $1,049,653 as PI
    • 1 of $31,727 as AI
    • 2 totalling $2,063,556 as Named Investigator
  • Internal Research Grants:
    • 3 totalling $97,000 as PI
    • 1 of $149,800 as AI

Total grants as PI or AI: $1,328,180
 

Grant details as PI - since 2009
2016-2018    Auckland Medical Research Foundation; project grant: Calcium balance in megakaryocytes; $144,945
2016-2018    Genesis Oncology Trust; project grant: Biology of megakaryocytic cancers; $50,000
2016-2018    Leukaemia & Blood Cancer NZ; project grant: New tools to study megakaryocytic cancers; $48,000
2013-2014    Lottery Health Research; equipment grant: Mindray BC5300 haematology analyser; $44,000
2012-2015    Child Cancer Foundation; project grant: NMDA receptors in megakaryoblastic leukaemia; $155,847
2012-ongoing

Funding from donation by Anne and David Norman and Family towards PhD fellowships for students together with the contribution towards their working expenses

2011-2014    Cancer Society; small project grant: NMDA receptors in melanoma; $15,000
2010-2013    Royal Society of New Zealand, Marsden Fast Start; project grant: Human antiplatelet autoantibodies; $300,000
2010-2011    Manchester Trust, School of Medicine Foundation; project grant: Glutamate signalling in acute megakaryoblastic leukaemia; $55,000
2010-2012    Freemasons NZ, School of Medicine Foundation; travelling fellowship: PJ Smith Fellowship; $22,000
2009-2012    Neurological Foundation; project grant: Anti NMDA-NR1 antibodies and damage from stroke; $131,861
 

Teaching | Current

  • MedSci 302 Cancer Biology: Cancer Hallmarks, Cancer Epidemiology, Tumour Microenvironment, Tumour Invasion and Metastasis, Tumour Angiogenesis, Impact of Oncogenes and Tumour Suppressors on Cancer Development and Progression - Clinical Examples, Integration of Morphology, Immunophenotyping and Genetics in Cancer Diagnosis and Research. Course Director.
  • MedSci 713 Principles of Cancer Therapy: Haematopoietic Stem Cell Transplantation, Cellular Therapies, Modulation of Tumour Environment. Course Coordinator and Director.
  • MedSci 714 Advanced Cancer Biology: Lymphoma Biology, Leukaemia Biology.
  • Contributes to other MEDSCI and MBChB teaching from stage 2 to 5 (2000-2015).

Postgraduate supervision

PhD Students:

  • 2015-present      James Hearn; main supervisor. Scholarship funded by the Leukaemia and Lymphoma PhD Fellowship from donation by Anne, Victoria and David Norman.
  • 2015-present      Sarvenaz Taghawi; co-supervisor
  • 2012-2016      Tania Kamal; main supervisor. Scholarship funded by the Leukaemia and Lymphoma PhD Fellowship from donation by Anne, Victoria and David Norman and the Doctoral Scholarship by the University of Auckland. Completed.
  • 2011-2016      Stacey D'mello; main supervisor. Scholarship funded by Auckland Medical Research Foundation. Completed.
  • 2012-2016      Alexander Trevarton; advisor. Completed.
  • 2010-2015      Thomas Chen; co-supervisor. Completed.

Master Students:

  • 2015    Yohanes Nursalim; main supervisor. Completed - First Class.
  • 2013    James Hearn; main supervisor. Completed - First Class.
  • 2012     Young-Eun Park; main supervisor. Completed - First Class.
  • 2012     Sugandha Chugh; main supervisor. Completed - Second Class.
  • 2011     Peng (Paul) Sun; main supervisor. Completed - First Class.
  • 2010     Thomas Chen; main supervisor. Completed - First Class.
  • 2009     Srividya Arunachalam; main supervisor.

Honours Students:   

  • 2006     Supinya Dejnoprat; main supervisor. Completed; First Class.
  • 2005     Alexander Trevarton; main supervisor. Completed; First Class

Summer Students:

  • 2015     Filip Nikolic; main supervisor
  • 2015     Alyona Oryshchuk; main supervisor.
  • 2013     James Hearn; main supervisor
  • 2012     Rushi Penumarthy; main supervisor.
  • 2011     Caroline Kang; main supervisor.
  • 2011     Rushi Penumarthy; main supervisor.
  • 2008     Acrane Li; main supervisor.
  • 2007     Vincent Chong; main supervisor. Report highly commended by the University of Auckland Judging Panel.
  • 2007     Farrah Rodrigues; main supervisor.
  • 2006     Isuru Dilshan; main supervisor.
  • 2005     Kathryn Goldstone; main supervisor. Report highly commended by the University of Auckland Judging Panel.
  • 2004     Alexander Trevarton; main supervisor.
  • 2003     Anika Lam; main supervisor.

Distinctions/Honours

2012    selected into Women in Leadership Programme, University of Auckland
2010    PJ Smith New Zealand Freemasons Travelling Fellowship to the University of Sydney
2010    Visiting Research Fellow, University of Sydney, Australia
2009    McBeath Child Cancer Award, School of Medicine Foundation, University of Auckland
2009    selected into the Forum of Academic Leaders, University of Auckland
2003    Best Doctoral Thesis Award, University of Auckland
1999    Registrar in Research Award, Royal College of Pathologists of Australasia
1998    Ruth Spencer Medical Research Fellowship, Auckland Medical Research Foundation
1997    Neil Prentice Memorial Prize for the Top Candidate in Pathological Sciences Examination in Australasia
1989    Gold Medal: Best Medical Graduate, Pomeranian Medical School, Poland
1989    Scholarship of the Polish Foundation Talent-Promotion-Progress, Ministry of Health, Poland

Responsibilities

  • Leads an idepedent research group into blood and cancer biology
  • Works as specialist haematologist at LabPlus, Auckland District Health  Board
  • Directs teaching into cancer biology and cancer therapy: MedSci 302 (Cancer Biology; 2009-present), MedSci 713 (Principles of Cancer Therapy; 2009-present) and MedSci 714 (Advanced Cancer Biology - 2009-2015)
  • Teaches cancer biology, experimental cancer therapy and clinical haematology in MedSci and MBChB courses

Areas of expertise

  • laboratory haematology
  • molecular haematology
  • leukaemia biology
  • haematopoiesis
  • megakaryocytes and platelets 
  • cancer biology
  • cancer research

Committees/Professional groups/Services

Committee functions:

  • Faculty Research Development Fund Committee, School of Medical Sciences, Member, 2009-2012.
  • Co-opted member of the Staff Advisory Committee for the School of Medical Sciences, 2013.

University Service:

  • HoD Nominee for 4 PhD theses examinations
  • Examiner of 1 PhD and 3 masters theses (two for the University of Otago)
  • Assessor of another 3 masters theses
  • Ad hoc Departmental Graduate Advisor 2015
  • DSAC advisor 2014
  • Review of VJU transgenic services 2014
  • Women in Leadership Programme , LabPlus, ADHB 2013
  • Provisional PhD year Reviewer for the School of Pharmacy 2013
  • Ad hoc referee for national funding agencies:
    • • Cancer Society of New Zealand
    • • Cure Kids
    • • Maurice and Phyllis Paykel Trust
  • Ad hoc referee for international journals:
    • • PLOS One
    • • Clinical Genetics
    • • Scientific Reports
    • • Internal Medicine Journal

Clinical service

I have gained Fellowship of the Royal College of Pathologists of Australasia in the specialty of Haematology in 2000. From 2000 to 2008 (during my PhD and post-doc), I worked evening sessions at the Diagnostic MedLab Community Laboratories, reviewing abnormal peripheral blood results, coagulation testing, haemoglobinopathy screens and immunophenotyping studies. My role was to interpret laboratory abnormalities to general practitioners, including advice on patient management. In 2005, I was appointed as Consultant Haematologist at LabPlus, Auckland District Health Board, initially on a temporary 0.2 FTE contract that became permanent in 2009 upon my appointment to Senior Lecturer at the UoA. My main role in the Haematology Laboratory is to diagnose disorders affecting bone marrow and peripheral blood, mostly haematological cancers but I also provide consultative haematology based on the pathology review of peripheral blood and bone marrow morphology abnormalities.

Main clinical competencies:

  • Diagnosis of acute and chronic leukaemias based on the integrated analysis of morphology, immunophenotyping and genetics according to the current WHO criteria
  • Bone marrow examination in the context of a wide range of haematological disease, from benign to malignant.
  • Staging of lymphomas and solid tumours in children and adults
  • General consultative haematology – in particular based on the analytic and morphology review of peripheral blood and bone marrow

Contributions to improve diagnostic service at LabPlus, ADHB:

  • Ongoing efforts to establish a platform for patient participation in biological research.
  • Established FISH methodology for routine diagnostic use at LabPlus Cytogenetics Laboratory. This work was performed together with Paul Oei and Daniel Ng, and with support from Dr Lochie Teague (Starship). 1999.
  • Established an immunofluorescent PML Protein Localisation Assay at LabPlus Haematology to allow rapid diagnosis of Acute Promyelocytic Leukaemia (APML). This work was performed with mentorship from Prof Peter Browett and help by Jan Nelson. 1999.

Professional groups:
2015 – present   Member, New Zealand Laboratory Haematology Study Group
2012 – present   Member, International Society on Thrombosis and Haemostasis (ISTH)
2010 – present   Member, Australasian Society of Thrombosis and Haemostasis (ASTH)
2007 – present   Member, American Society of Hematology (ASH)
2004 – 2009       Member, Society for Neuroscience (SFN)
1998 – present   Member, Haematology Society of Australia and New Zealand (HSANZ)

Selected publications and creative works (Research Outputs)

Identifiers

Contact details

Alternative contact

LabPlus Haematology, Auckland District Health Board

Primary location

M&HS BUILDING 502 - Bldg 502
Level 2, Room 201F
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Social links

Web links