Dr Jacelyn Mei San Loh

PhD in Molecular Biology

Biography

Dr. Jacelyn Loh is a Senior Research Fellow in the infection and immunity cluster in the department of Molecular Medicine and Pathology. Her research focus is in vaccine development against Streptococcus pyogenes, the triggering agent of rheumatic fever.

Research | Current

Streptococcus pyogenes or Group A streptococcus (GAS) is a gram positive bacterium that can cause a wide variety of diseases ranging from pharyngitis and tonsillitis to severe invasive diseases, such as necrotizing fasciitis (“flesh eating disease”) and streptococcal toxic shock syndrome. Streptococcal sequela, which includes glomerulonephritis and acute rheumatic fever, are often complications of streptococcal infection and remain a significant problem in NZ. Present research is in multivalent vaccine design and in understanding the immune responses to infection and vaccines.

Teaching | Current

BIOSCI399

MEDSCI705

Postgraduate supervision

Current students:

Haniyeh Aghababa (PhD)

Tiger Aspell (PhD)

Distinctions/Honours

2020-2023 National Heart Foundation Senior Research Fellowship

2016-2019 National Heart Foundation Research Fellowship

Areas of expertise

Microbiology and Immunology

Committees/Professional groups/Services

Committee member of the FMHS Post-doc Society

Member of the Australasian Society for Immunology

Member of the NZ Microbiological Society

Selected publications and creative works (Research Outputs)

As of 29 October 2020 there will be no automatic updating of 'selected publications and creative works' from Research Outputs. Please continue to keep your Research Outputs profile up to date.
  • Young, P. G., Raynes, J. M., Loh, J. M., Proft, T., Baker, E. N., & Moreland, N. J. (2019). Group A Streptococcus T Antigens Have a Highly Conserved Structure Concealed under a Heterogeneous Surface That Has Implications for Vaccine Design. Infection and immunity, 87 (6).10.1128/IAI.00205-19
    Other University of Auckland co-authors: Thomas Proft, Paul Young, Nikki Moreland, Edward Baker
  • Soh, K. Y., Loh, J. M. S., & Proft, T. (2018). Orthologues of Streptococcus pyogenes nuclease A (SpnA) and Streptococcal 5'-nucleotidase A (S5nA) found in Streptococcus iniae. Journal of biochemistry, 164 (2), 165-171. 10.1093/jb/mvy039
    Other University of Auckland co-authors: Thomas Proft
  • Jones, S., Moreland, N. J., Zancolli, M., Raynes, J., Loh, J. M. S., Smeesters, P. R., ... Goldblatt, D. (2018). Development of an opsonophagocytic killing assay for group a streptococcus. Vaccine, 36 (26), 3756-3763. 10.1016/j.vaccine.2018.05.056
    Other University of Auckland co-authors: John Fraser, Nikki Moreland
  • Wagachchi, D., Tsai, J.-Y. C., Chalmers, C., Blanchett, S., Loh, J. M. S., & Proft, T. (2018). PilVax - a novel peptide delivery platform for the development of mucosal vaccines. Scientific Reports, 8, 1-12. 10.1038/s41598-018-20863-7
    Other University of Auckland co-authors: Thomas Proft, Catherine Tsai
  • Loh, J., Tsai, J.-Y., & Proft, T. (2017). The ability of Group A streptococcus to adhere to immortalized human skin versus throat cell lines does not reflect their predicted tissue tropism. Clinical Microbiology and Infection, 23 (9), 677.e1-677.e3. 10.1016/j.cmi.2017.03.011
    Other University of Auckland co-authors: Catherine Tsai, Thomas Proft
  • Loh, J. M., Lorenz, N., Tsai, C. J.-Y., Khemlani, A. H. J., & Proft, T. (2017). Mucosal vaccination with pili from Group A Streptococcus expressed on Lactococcus lactis generates protective immune responses. Scientific Reports, 710.1038/s41598-017-07602-0
    Other University of Auckland co-authors: Catherine Tsai, Thomas Proft, Natalie Lorenz
  • Lorenz, N., Loh, J. M. S., Moreland, N. J., & Proft, T. (2017). Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against Streptococcus pyogenes using bioluminescence. Journal of Microbiological Methods, 134, 58-61. 10.1016/j.mimet.2017.01.010
    Other University of Auckland co-authors: Thomas Proft, Nikki Moreland, Natalie Lorenz
  • Chalmers, C., Khemlani, A. H. J., Sohn, C. R., Loh, J. M. S., Tsai, C. J.-Y., & Proft, T. (2017). Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity. Journal of Microbiology, Immunology and Infection10.1016/j.jmii.2017.09.006
    Other University of Auckland co-authors: Thomas Proft, Catherine Tsai

Identifiers

Contact details

Office hours

8am-4pm

Primary office location

M&HS BUILDING 502 - Bldg 502
Level 3, Room 301
85 PARK RD
NZL
AUCKLAND 1023
New Zealand

Web links