Dr Natasha Lillia Grimsey

PhD Pharmacology, BCom/BSc(Hons)

Research | Current

Dr Natasha Grimsey is a postdoctoral research fellow in the Receptor Signalling Lab (PI: Professor Michelle Glass).

Natasha's research focuses on G protein-coupled receptor signalling and intracellular trafficking, with emphasis on the cannabinoid receptors and how these influence normal physiology and disease, as well as the development of quantitative assays utilising high-throughput techniques.

Publications

Teaching | Current

Lecturer, MedSci304 Molecular Pharmacology

Postgraduate supervision

Current

David Finlay (PhD co-supervisor)

Caitlin Oyagawa (PhD primary supervisor)

Yurii Saroz (PhD primary supervisor)


Completed

Caitlin Oyagawa (2016, Masters primary supervisor)

Morag Hunter (2015, PhD co-supervisor)

Braden Woodhouse (2014, Honours primary supervisor)

David Finlay (2014, Masters co-supervisor)

Karan Govindpani (2014, Honours co-supervisor)

Summer students: Samuel King (2014), David Finlay (2013), AJ Sykes (2008)

Areas of expertise

  • Cannabinoids
  • Cannabinoid receptors 1 and 2 (CB1 & CB2)
  • G-protein coupled receptor trafficking and signalling
  • Receptor intracellular trafficking
  • Neuropharmacology
  • High content analysis and high throughput screening

Selected publications and creative works (Research Outputs)

  • Finlay, D., Cawston, E., Grimsey, N., Hunter, M., Korde, A., Vemuri, V., ... Glass, M. (2017). Gαs signalling of the CB₁ receptor and the influence of receptor number. British Journal of Pharmacology, 174 (15), 2545-2562. 10.1111/bph.13866
    URL: http://hdl.handle.net/2292/35307
    Other University of Auckland co-authors: David Finlay, Michelle Glass, Erin Cawston
  • Hunter, M. R., Finlay, D. B., Macdonald, C. E., Cawston, E. E., Grimsey, N. L., & Glass, M. (2017). Real-Time Measurement of Cannabinoid Receptor-Mediated cAMP Signaling. Methods in enzymology, 593, 43-59. 10.1016/bs.mie.2017.05.001
    Other University of Auckland co-authors: Michelle Glass, Erin Cawston, David Finlay
  • Finlay, D. B., Joseph, W. R., Grimsey, N. L., & Glass, M. (2016). GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine. PeerJ, 410.7717/peerj.1835
    URL: http://hdl.handle.net/2292/30934
    Other University of Auckland co-authors: Michelle Glass, Wayne Joseph, David Finlay
  • Redmond, W. J., Cawston, E. E., Grimsey, N. L., Stuart, J., Edington, A. R., Glass, M., & Connor, M. (2016). Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors. British journal of pharmacology, 173 (1), 115-127. 10.1111/bph.13341
    Other University of Auckland co-authors: Erin Cawston, Michelle Glass
  • Dowie, M. J., Grimsey, N. L., Hoffman, T., Faull, R. L. M., & Glass, M. (2014). Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain. Journal of chemical neuroanatomy, 59-60, 62-71. 10.1016/j.jchemneu.2014.06.004
    Other University of Auckland co-authors: Michelle Glass, Richard Faull
  • Cawston, E. E., Redmond, W. J., Breen, C. M., Grimsey, N. L., Connor, M., & Glass, M. (2013). Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol, 170 (4), 893-907. 10.1111/bph.12329
    Other University of Auckland co-authors: Michelle Glass, Erin Cawston
  • Hunter, M., Grimsey, N. L., & Glass, M. (1/1/2013). Constitutive heterodimerisation of cannabinoid CB1 and dopamine D2 receptors revealed using bioluminescence resonance energy transfer (BRET) assay. Poster presented at Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) New Zealand Annual Scientific Meeting., Queenstown, NZ. Related URL.
    Other University of Auckland co-authors: Michelle Glass
  • Grimsey, N. L., Gunasekara, D., Cawston, E., Goodfellow, C. E., & Glass, M. (2012). Unusual Trafficking of Cannabinoid Receptor 2: Agonist-Induced Upregulation of Surface Receptors. Paper presented at 22nd International Research Symposium on the Cannabinoids, International Cannabinoid Research Society (ICRS), Freiburg im Breisgau, Germany. 22 July - 27 July 2012. Related URL.
    Other University of Auckland co-authors: Erin Cawston, Michelle Glass

Identifiers

Contact details

Primary location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 501
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Social links

Web links