Dr Nishi Karunasinghe

PhD Macquarie University, Sydney, Australia

Biography

My main research focus has been on selenium health benefit and genetic studies on prostate cancer (PC). 
Next target of my career is to work with replication PC cohorts from large scale studies to reproduce our findings. A collaboration study with the National Cancer Institute, USA has shown a significant delayed diagnosis of high-risk PC in New Zealand compounded by tobacco smoking and the aldo-keto reductase 1C3 rs12529 genotype.  
I was invited to present two concepts at the Australia and New Zealand Urogenital and Prostate Cancer Trials group (ANZUP) in Australia. One was to replicate our findings on genetic association on quality of life (QoL) effects with ADT in a cohort currently receiving enzalutamide. The other was on developing PSA thresholds based on genetics. Two of my international presentations have been named as among the best of the best. Disparities in PC diagnoses and QoL effects with ADT on Mãori men have been presented to the Mãori Health Committee as well as at a Cancer Health Disparities in Minorities conference in the US. I have published 34 research articles and three book chapters related to my work.

Research | Current

Genetic associations of prostate cancer diagnosis, treatment and prognosis outcomes. Genetic association of selenium health benefits. 

Teaching | Current

 I have supervised 15 Summer Student working on prostate cancer related projects.

Postgraduate supervision

I have supervised two PhD students on aspects related to prostate cancer. Currently supervising a Master's student on a study that verifies the influence of Maori medicinal plants in modulating prostate cancer progression using an in vitro model.

Distinctions/Honours

Australia New Zealand Urogenital and Prostate Cancer Trials Group Annual Scientific Meeting (ASM) 2017, Melbourne Australia and ASM 2016 Brisbane, Australia- Best of the Best poster presentations at both instances. Received  Bayer Travel Fellowship for both. 

Selected publications and creative works (Research Outputs)

  • Karunasinghe, N., Symes, E., Gamage, A., Wang, A., Murray, P., Zhu, S., ... Ferguson, L. R. (2019). Interaction between leukocyte aldo-keto reductase 1C3 activity, genotypes, biological, lifestyle and clinical features in a prostate cancer cohort from New Zealand. PloS one, 14 (5)10.1371/journal.pone.0217373
    Other University of Auckland co-authors: Lynnette Ferguson
  • Karunasinghe, N., Ambs, S., Wang, A., Tang, W., Zhu, S., Dorsey, T. H., ... Ferguson, L. R. (2018). Influence of lifestyle and genetic variants in the aldo-keto reductase 1C3 rs12529 polymorphism in high-risk prostate cancer detection variability assessed between US and New Zealand cohorts. PloS one, 13 (6)10.1371/journal.pone.0199122
    Other University of Auckland co-authors: Lynnette Ferguson
  • Vaidyanathan, V., Karunasinghe, N., Krishnamurthy, V., Kao, C. H.-J., Naidu, V., Pallati, R., ... Jabed, A. (2017). Aggressive prostate cancer incidence in New Zealand-"united we fall, divided we stand". The New Zealand Medical Journal, 130 (1466), 96-99.
    URL: http://hdl.handle.net/2292/44538
    Other University of Auckland co-authors: Prasanna Kallingappa, Clare Wall, Lynnette Ferguson, Khanh Tran
  • Asadi, K., Ferguson, L. R., Philpott, M., & Karunasinghe, N. (2017). Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model. Journal of Cancer Prevention, 22 (3), 135-146. 10.15430/jcp.2017.22.3.135
    URL: http://hdl.handle.net/2292/42894
    Other University of Auckland co-authors: Lynnette Ferguson
  • Vaidyanathan, V., Naidu, V., Karunasinghe, N., Kao, C. H.-J., Pallati, R., Jabed, A., ... Ferguson, L. R. (2017). Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population. Molecular BioSystems10.1039/c7mb00203c
    URL: http://hdl.handle.net/2292/44051
    Other University of Auckland co-authors: Lynnette Ferguson, Prasanna Kallingappa
  • Venkatesh, V., Vijay, N., Kao, C., Karunasinghe, N., Bishop, K., Wang, A., ... Zhu, S. (2017). Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men: A genotypic approach. Molecular BioSystems, 13 (4), 681-698. 10.1039/C6MB00873A
    URL: http://hdl.handle.net/2292/33628
    Other University of Auckland co-authors: Phillip Shepherd, Lynnette Ferguson
  • Wang, A., Karunasinghe, N., Plank, L., Zhu, S., Osborne, S., Bishop, K., ... Holmes, M. (2017). Effect of androgen deprivation therapy on bone mineral density in a prostate cancer cohort in New Zealand: A pilot study. Clinical Medicine Insights: Oncology, 1110.1177/1179554917733449
    URL: http://hdl.handle.net/2292/44362
    Other University of Auckland co-authors: Lindsay Plank, Lynnette Ferguson, Alice Wang
  • Vaidyanathan, V., Naidu, V., Karunasinghe, N., Jabed, A., Pallati, R., & Marlow, G. (2017). SNP-SNP interactions as risk factors for aggressive prostate cancer. F1000Research, 610.12688/f1000research.11027.1
    URL: http://hdl.handle.net/2292/42493
    Other University of Auckland co-authors: Lynnette Ferguson

Identifiers

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 0, Room 016
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links