Dr Nikki Moreland
BSc Waik., PhD Auck.
Dr Nikki Moreland is a Senior Lecturer in Immunology and joined the faculty as a member of staff in 2016. Nikki obtained her PhD from the University of Auckland and was previously a research fellow in the School of Biological Sciences, Auckland and Duke-NUS Graduate Medical School, Singapore. She has also held positions in the British pharmaceutical industry bringing a translational element to her research.
Research | Current
Dr. Moreland’s laboratory studies the mechanisms that drive antibody specificity using a combination of protein biochemistry and molecular biology. The laboratory seeks to better understand how a functional antibody repertoire can protect against infection, yet dysregulation of the immune system produces autoantibodies that can attack the body’s own tissues.
The major research focus of the laboratory is rheumatic fever, an autoimmune disease that can develop after an untreated Group A Streptococcus infection. Globally, Group A Streptococcus is placed in the ‘top 10’ infectious causes of human death. The rates of rheumatic fever in Māori and Pacific children in New Zealand are amongst the highest in the world, and the disease pathology is poorly understood.
The laboratory is profiling the antibody repertoires of patients with rheumatic fever using a variety of technologies including high content protein arrays and antibody phage display. Mapping the antibody specificities in rheumatic fever will improve understanding of the disease and contribute to the development of better diagnostics.
The group is also involved in efforts to develop new vaccines for Group A Streptococcus. Biochemical and biophysical techniques are used to elucidate the molecular mechanisms by which antibodies recognise potential vaccine antigens to inform vaccine design.
Current lab members
- Dr Reuben McGregor, postdoctoral research fellow
- Dr Natalie Lorenz, postdoctoral research fellow
- Mei Lin Tay, research technician
- Jeremy Raynes, PhD student
- Alana Whitcombe, PhD student
- Timothy Ho, BBioMedSc Honours student
- Franklin Han, BMedSci Honours student
Teaching | Current
MEDSCI 708: Advanced Immunology (Course Director)
MEDSCI 202: Microbiology and Immunology
MEDSCI 301: Molecular Basis of Disease
MEDSCI 314: Immunology
BIOSCI 349: Biomedical Microbiology
Areas of expertise
Antibody technology, Infectious disease
Selected publications and creative works (Research Outputs)
- Jones, S., Moreland, N. J., Zancolli, M., Raynes, J., Loh, J. M. S., Smeesters, P. R., ... Goldblatt, D. (2018). Development of an opsonophagocytic killing assay for group a streptococcus. Vaccine, 36 (26), 3756-3763. 10.1016/j.vaccine.2018.05.056
Other University of Auckland co-authors: John Fraser, Jacelyn Loh, Jeremy Raynes
- Sikder, S., Williams, N. L., Sorenson, A. E., Alim, M. A., Vidgen, M. E., Moreland, N. J., ... Norton, R. E. (2018). Group G Streptococcus Induces an Autoimmune Carditis Mediated by Interleukin 17A and Interferon γ in the Lewis Rat Model of Rheumatic Heart Disease. The Journal of infectious diseases, 218 (2), 324-335. 10.1093/infdis/jix637
- Hanson-Manful, P., Whitcombe, A. L., Young, P. G., Atatoa Carr, P. E., Bell, A., Didsbury, A., ... Moreland, N. J. (2018). The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. Journal of Infection, 76 (4), 361-368. 10.1016/j.jinf.2017.12.008
Other University of Auckland co-authors: Thomas Proft, Paul Young, Edwin Mitchell, Rod Dunbar, Alicia Didsbury, Alana Whitcombe
- Oliver, J., Malliya Wadu, E., Pierse, N., Moreland, N. J., Williamson, D. A., & Baker, M. G. (2018). Group A Streptococcus pharyngitis and pharyngeal carriage: A meta-analysis. PLoS neglected tropical diseases, 12 (3)10.1371/journal.pntd.0006335
- Raynes, J. M., Young, P. G., Proft, T., Williamson, D. A., Baker, E. N., & Moreland, N. J. (2018). Protein adhesins as vaccine antigens for Group A Streptococcus. Pathogens and disease, 76 (2).10.1093/femspd/fty016
Other University of Auckland co-authors: Thomas Proft, Paul Young, Edward Baker, Jeremy Raynes
- O'Sullivan L, Moreland, N. J., Webb, R. H., Upton, A., & Wilson, N. J. (2017). Acute rheumatic fever after Group A Streptococcus pyoderma and Group G Streptococcus pharyngitis. Pediatric Infectious Disease Journal, 36 (7), 692-694. 10.1097/INF.0000000000001558
Other University of Auckland co-authors: Rachel Webb
- Schödel F, Moreland, N. J., Wittes, J. T., Mulholland, K., Frazer, I., Steer, A. C., ... Carapetis, J. (2017). Clinical development strategy for a candidate group A streptococcal vaccine. Vaccine, 35 (16), 2007-2014. 10.1016/j.vaccine.2017.02.060
Other University of Auckland co-authors: John Fraser
- Lorenz, N., Loh, J. M. S., Moreland, N. J., & Proft, T. (2017). Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against Streptococcus pyogenes using bioluminescence. Journal of Microbiological Methods, 134, 58-61. 10.1016/j.mimet.2017.01.010
Other University of Auckland co-authors: Jacelyn Loh, Thomas Proft, Natalie Lorenz