Mrs Lola Mugisho

Master of Science (Hons) in Biomedical Science

Profile Image
Doctoral Candidate - Doctor of Philosophy

Research | Current

My current research investigates the role of gap junction proteins (connexins) in diabetic retinopathy with a primary focus on vascular disruptions seen in the disease. My research aims to:

  • Develop a diabetic retinopathy model that characterises connexin43 changes seen in human tissues,
  • Describe the role of connexins and its contribution to the pathology of diabetic retinopathy,
  • Evaluate possible connexin-based therapies for the treatment of diabetic retinopathy.


International Gap Junction Conference (IGJC) Travel Award (2017)

Buchanan Ocular Therapeutics Unit Doctoral Scholarship (2015)

Faculty of Science Masters Awards (2013)

FMHS Summer Studentship Scholarship (2012/2013)


Areas of expertise

  • Animal handling
  • in vivo rodent retinal imaging techniques (Fundus Imaging and Spectral Domain-Optical Coherence Tomography (OCT)
  • Cell culture
  • Western blotting
  • Flow cytometry
  • Cytometric Bead Array (CBA)
  • Spectrophotometry
  • Confocal cell and tissue imaging
  • Tissue sectioning using a cryostat
  • Immunocytochemistry
  • Immunohistochemistry


Selected publications and creative works (Research Outputs)

  • Mugisho, O. O., Green, C. R., Zhang, J., Binz, N., Acosta, M. L., Rakoczy, E., & Rupenthal, I. D. (2017). Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int J Mol Sci, 18 (12).10.3390/ijms18122567
    Other University of Auckland co-authors: Colin Green, Jie Zhang, Monica Acosta, Ilva Rupenthal
  • Mugisho, O. O., Green, C. R., Kho, D. T., Zhang, J., Scott Graham, E., Acosta, M. L., & Rupenthal, I. D. (2017). The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release. Biochimica et biophysica acta10.1016/j.bbagen.2017.11.015
    Other University of Auckland co-authors: Ilva Rupenthal, Colin Green, Monica Acosta, Scott Graham, Jie Zhang
  • Rotimi, O. O., Green, C., Zhang, J., Acosta, M. L., & Rupenthal, I. (2016). Increased Connexin43 expression in a mouse model of advanced diabetic retinopathy. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA. 1 May - 5 May 2016. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
    Other University of Auckland co-authors: Colin Green, Ilva Rupenthal, Monica Acosta
  • Choi, J. M., Rotimi, O. O., O'Carroll SJ, & Nicholson, L. F. B. (2016). IL-6 stimulates a concentration-dependent increase in MCP-1 in immortalised human brain endothelial cells. F1000Research, 510.12688/f1000research.8153.2
    Other University of Auckland co-authors: Simon OCarroll
  • O'Carroll SJ, Kho, D. T., Wiltshire, R., Nelson, V., Rotimi, O., Johnson, R., ... Graham, E. S. (2015). Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. Journal of neuroinflammation, 1210.1186/s12974-015-0346-0
    Other University of Auckland co-authors: Scott Graham, Simon OCarroll, Catherine Angel, Dan Kho
  • Rotimi, O. O. (2013). Influence of Downstream Peripheral Inflammation Markers on an in vitro Model of the Blood-Brain Barrier The University of Auckland. ResearchSpace@Auckland.


Contact details

Primary location

M&HS BUILDING 504 - Bldg 504
Level 4, Room 416
New Zealand

Web links