Dr Peter Jaein Choi

BSc(hons) PhD in Chemistry, University of Auckland

Research Fellow

In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Peter Choi obtained his BSc (hons) in medicinal chemistry and PhD in synthetic organic chemistry at the University of Auckland with Dist. Prof. Margaret Brimble. After completion of his PhD, Peter was appointed as a research fellow working with Dist. Prof. Bill Denny and Assoc. Prof. Brian Palmer at the Auckland Cancer Society Research Centre as a medicinal chemist to design and synthesise novel drugs for tuberculosis. He is an affiliate investigator in the Maurice Wilkins Centre for Molecular Biodiscovery at the University of Auckland.

Research | Current

- Working with the Global Alliance for Tuberculosis Drug Development (TB Alliance), to develop novel and affordable drugs for the treatment of tuberculosis. The top two compounds from the previous project (development of 2nd generation analogues of bedaquiline) are undergoing preclinical evaluation and is scheduled for clinical evaluation shortly. Various other projects are ongoing with TB Alliance including targeting novel kinases specific for survival of TB.

https://www.fmhs.auckland.ac.nz/en/sms/about/our-departments/auckland-cancer-society-research-centre/research-groups/medicinal-chemistry/targeting-tb.html

- Other research interests include development of novel cancer drugs for the treatment of glioblastomas.

- Any potential chemsitry interns/students interested in working at the ACSRC, please contact Peter

Teaching | Current

MEDSCI745- Drug Development

CHEM750- Cancer drugs: Design, Chemistry and Mechanism of Action

Postgraduate supervision

BSc (hon) Project

Improving the therapeutic potential of TKIs for the treatment of GBM: Conjugation with Heptamethine Cyanine Dyes

Elizabeth Cooper (co-supervisor)

Areas of expertise

Organic Chemistry

Medicinal Chemistry

Natural Products

Antituberculosis Agents

Drug Discovery

Committees/Professional groups/Services

1. Allifiate Investigator, Maurice Wilkins Centre

2. Member of Amercian Chemical Society

3. Member of New Zealand Institute of Chemistry

4. Member of the International Union of Crystallography

5. Council member of Korean Academy of Scientists and Engineers in Australasia (KASEA)

Selected publications and creative works (Research Outputs)

Choi, P. J., Cooper, E., Schweder, P., Mee, E., Turner, C., Paull, R., ... Jose, J. (2020). PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 30 (14)10.1016/j.bmcl.2020.127252
URL: http://hdl.handle.net/2292/51570
Other University of Auckland co-authors: Bill Denny, Michael Dragunow, Thomas Park, Jiney Jose, Richard Faull
Choi, P. J., Conole, D., Sutherland, H. S., Blaser, A., Tong, A. S. T., Cooper, C. B., ... Denny, W. A. (2020). Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogueof Bedaquiline. Molecules (Basel, Switzerland), 25 (6).10.3390/molecules25061423
Other University of Auckland co-authors: Adrian Blaser, Bill Denny, Brian Palmer
Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Palmer, B. D. (2020). Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology. Bioorganic & medicinal chemistry, 28 (1)10.1016/j.bmc.2019.115213
Other University of Auckland co-authors: Adrian Blaser, Bill Denny, Brian Palmer
Choi, P. J., Cooper, E., Schweder, P., Mee, E., Faull, R., Denny, W. A., ... Jose, J. (2019). The synthesis of a novel Crizotinib heptamethine cyanine dye conjugate that potentiates the cytostatic and cytotoxic effects of Crizotinib in patient-derived glioblastoma cell lines. Bioorganic and Medicinal Chemistry Letters, 29 (18), 2617-2621. 10.1016/j.bmcl.2019.07.051
URL: http://hdl.handle.net/2292/48221
Other University of Auckland co-authors: Thomas Park, Richard Faull, Bill Denny, Michael Dragunow, Jiney Jose
Blaser, A., Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. Bioorganic & medicinal chemistry, 27 (7), 1283-1291. 10.1016/j.bmc.2019.02.025
Other University of Auckland co-authors: Bill Denny, Adrian Blaser, Brian Palmer
Sutherland, H. S., Tong, A. S. T., Choi, P. J., Blaser, A., Conole, D., Franzblau, S. G., ... Denny, W. A. (2019). 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorganic & medicinal chemistry, 27 (7), 1292-1307. 10.1016/j.bmc.2019.02.026
Other University of Auckland co-authors: Bill Denny, Brian Palmer, Adrian Blaser
Jose, J., Choi, P., Noguchi, K., Ishiyama, M., & Denny, W. (31/3/2019). Synthesis of near-infrared emitting fluorescent dyes and their application in organelle specific labelling studies. Poster presented at 257th National Meeting of the American-Chemical-Society (ACS), Orlando, FL. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
Other University of Auckland co-authors: Jiney Jose, Bill Denny
Choi, P., Sutherland, H., Tong, A., Conole, D., Blaser, A., Cooper, C., ... Palmer, B. (31/3/2019). Next-generation bedaquiline for the treatment of tuberculosis. Poster presented at 257th National Meeting of the American-Chemical-Society (ACS), Orlando, FL. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
Other University of Auckland co-authors: Adrian Blaser, Bill Denny, Brian Palmer