Dr Peter Jaein Choi

BSc(hons) PhD in Chemistry, University of Auckland

Research Fellow

In: Auckland Cancer Society Research Centre » Medical Science » Faculty of Medical and Health Sciences

Biography

Peter Choi obtained his BSc (hons. 1st class) in Medicinal Chemistry and PhD in Synthetic Organic Chemistry at the University of Auckland with Dist. Prof. Margaret Brimble. After completion of his PhD, Peter was appointed as a research fellow working with Dist. Prof. Bill Denny and Assoc. Prof. Brian Palmer at the Auckland Cancer Society Research Centre to design and synthesise novel drugs for the treatment of tuberculosis.

Research | Current

Working as a medicinal chemist in a collaborative project with the Global Alliance for Tuberculosis Drug Development (TB Alliance) in New York, which seeks to develop novel and affordable drugs for the treatment of tuberculosis.

Areas of expertise

Organic Chemistry

Medicinal Chemistry

Natural Products

Antituberculosis Agents

Selected publications and creative works (Research Outputs)

Choi, P., Noguchi, K., Ishiyama, M., Denny, W. A., & Jose, J. (2018). A mitochondria-selective near-infrared-emitting fluorescent dye for cellular imaging studies. Bioorganic & medicinal chemistry letters, 28 (11), 2013-2017. 10.1016/j.bmcl.2018.05.001
Other University of Auckland co-authors: Jiney Jose, Bill Denny
Sutherland, H. S., Tong, A. S. T., Choi, P. J., Conole, D., Blaser, A., Franzblau, S. G., ... Denny, W. A. (2018). Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles. Bioorganic & medicinal chemistry, 26 (8), 1797-1809. 10.1016/j.bmc.2018.02.026
Other University of Auckland co-authors: Adrian Blaser, Bill Denny, Brian Palmer, Hamish Sutherland
Choi, P. J., Sutherland, H. S., Tong, A. S., Blaser, A., Franzblau, S. G., Cooper, C. B., ... Motte, M. (2017). Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units. Bioorganic and Medicinal Chemistry Letters, 27 (23), 5190-5196. 10.1016/j.bmcl.2017.10.042
Other University of Auckland co-authors: Hamish Sutherland, Adrian Blaser, Bill Denny, Brian Palmer
Tong, A. S., Choi, P. J., Blaser, A., Sutherland, H. S., Tsang, S. K., Guillemont, J., ... Van den Broeck, W. (2017). 6-cyano analogues of bedaquiline as less lipophilic and potentially safer diarylquinolines for tuberculosis. ACS Medicinal Chemistry Letters, 8 (10), 1019-1024. 10.1021/acsmedchemlett.7b00196
Other University of Auckland co-authors: Adrian Blaser, Hamish Sutherland, Bill Denny, Brian Palmer
Choi, P. J., Tong, S. T., Denny, W. A., Palmer, B. D., Blaser, A., Conole, D., ... Upton, A. M. (7/9/2017). Synthetic studies towards the development of less lipophilic drug of bedaquiline. Poster presented at Queenstown Research Week, Rydges Hotel, Queenstown, New Zealand. National Symposium on Infectious Diseases: key opportunities and emerging therapies.
Other University of Auckland co-authors: Bill Denny, Brian Palmer, Adrian Blaser, Hamish Sutherland
Choi, P. J. (2011). Synthetic Studies Towards Aromatic Polyketide Derived Natural Products The University of Auckland. ResearchSpace@Auckland.
URL: http://hdl.handle.net/2292/6978
Choi, P. J., Sperry, J., & Brimble, M. A. (2010). Heteroatom-directed reverse Wacker oxidations. Synthesis of the reported structure of (-)-herbaric acid. J Org Chem, 75 (21), 7388-7392. 10.1021/jo1016585
URL: http://hdl.handle.net/2292/7981
Other University of Auckland co-authors: Margaret Brimble, Jonathan Sperry
Choi, P. J., Rathwell, D. C. K., & Brimble, M. A. (2009). Synthesis of 6,6-Bisbenzannulated Spiroketals Related to the Rubromycins Using a Double Intramolecular Hetero-Michael Addition (DIHMA). Tetrahedron Letters, 50 (26), 3245-3248. 10.1016/j.tetlet.2009.02.030
URL: http://hdl.handle.net/2292/8146
Other University of Auckland co-authors: Margaret Brimble