Professor Paul James Donaldson

BSc, PhD (Otago)

Biography

Paul is the Director of the Molecular Vision Laboratory and is currently the Head of the School of Medical Sciences.

He obtained his PhD in field of epithelial transport from the Department of Physiology at the University of Otago in 1987, and this was followed by Post Doctoral Fellowships at Yale University and the University of Texas Medical Branch in Galveston. In 1990 he returned to New Zealand to take up a research position in the then Department of Cellular and Molecular Biology at The University of Auckland. This marked the start of a long and productive collaboration with Professor Joerg Kistler on the lens cataract research. In 1997 Dr Donaldson accepted a tenured position in the Department of Physiology at Auckland where he set up the Molecular Vision Laboratory. In 2004 he was promoted to Associate Professor and later in that year also became Head of Department.In 2008 he was appointed to the Chair in Optometry and Vision Science and assumed the leadership of the Department of Optometry and Vision Science and oversaw the transfer of the Department from the Faculy of Science to the Faculty of Medical and Health Sciences. In 2012 Paul was appointed as the Head of the School of Medical Sciences.

Paul built an international reputation as a vision research scientist. His research has been supported by numerous funding agencies including the Health Research Council, Wellcome Trust UK, Marsden Fund, Auckland Medical Research Foundation, Paykell Trust, Lotteries Health and the National Institutes of Health, USA.

He has been actively involved in the International Society of Eye Research (ISER) and the Association of Research in Vision and Ophthalmology for many years as a reviewer, keynote speaker and symposia organizer. He served as the Vice President (Pacific Rim) of ISER and is the Deputy Director of New Zealand National Eye Centre (NZ-NEC), a cross faculty center between Optometry and Vision Science, Ophthalmology and the Molecular Vision Laboratory.

Research | Current

The Molecular Vision Laboratory has extensive molecular and cellular expertise in the general field of membrane transport. Members of the laboratory utilize electrophysiology, imaging, biochemistry, proteomics, molecular biology, and computer modeling to determine how the properties of ion channels and transporters contribute to the integrative function of ocular tissues that comprise the front of the eye. Current research projects in the lens are focused on determining how the interaction of a variety of ion channels and transporters contribute to the maintenance of lens transparency.

Responsibilities

Head of School School of Medical Sciences

Honorary Professor Department of Optometry and Vision Science

Honorary Professor, Department of Physiology

Associate Investigator Maurice Wilkins Centre for Biodiscovery,

                   

Selected publications and creative works (Research Outputs)

  • Martis, R. M., Donaldson, P. J., Li, B., Middleditch, M., Kallingappa, P. K., & Lim, J. C. (2019). Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance. Histochemistry and cell biology, 152 (4), 293-310. 10.1007/s00418-019-01805-4
    Other University of Auckland co-authors: Julie Lim, Prasanna Kallingappa
  • Pan, X., Lie, A. L., White, T. W., Donaldson, P. J., & Vaghefi, E. (2019). Development of an in vivo magnetic resonance imaging and computer modelling platform to investigate the physiological optics of the crystalline lens. Biomedical optics express, 10 (9), 4462-4478. 10.1364/BOE.10.004462
    Other University of Auckland co-authors: Alyssa Lie, Ehsan Vaghefi, Wilson Pan
  • Nakazawa, Y., Donaldson, P. J., & Petrova, R. S. (2019). Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Experimental eye research, 18610.1016/j.exer.2019.107707
    Other University of Auckland co-authors: Rosica Petrova
  • Demarais, N. J., Donaldson, P. J., & Grey, A. C. (2019). Age-related spatial differences of human lens UV filters revealed by negative ion mode MALDI imaging mass spectrometry. Experimental eye research, 184, 146-151. 10.1016/j.exer.2019.04.016
    Other University of Auckland co-authors: Gus Grey, Nicholas Demarais
  • Braakhuis, A. J., Donaldson, C. I., Lim, J. C., & Donaldson, P. J. (2019). Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies. Nutrients, 11 (5).10.3390/nu11051186
    Other University of Auckland co-authors: Andrea Braakhuis, Julie Lim
  • Martis, R. M., Donaldson, P. J., & Lim, J. C. (2019). Corneal opacities in mice exposed to repeated contact procedures during ocular examinations. Clinical and Experimental Optometry10.1111/cxo.12934
    Other University of Auckland co-authors: Julie Lim
  • Vaghefi, E., & Donaldson, P. J. (2018). The lens internal microcirculation system delivers solutes to the lens core faster than would be predicted by passive diffusion. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 315 (5), R994-R1002. 10.1152/ajpregu.00180.2018
    URL: http://hdl.handle.net/2292/45530
    Other University of Auckland co-authors: Ehsan Vaghefi
  • Donaldson, P. J., Perwick, R., Li, I., Demarais, N. J., Lim, J. C., & Grey, A. (2018). Mapping glucose metabolism pathways in the bovine lens using imaging mass spectrometry. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI. 29 April - 3 May 2018. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 3).
    Other University of Auckland co-authors: Julie Lim, Gus Grey

Identifiers

Contact details

Alternative contact

Laboratory Office

M&HS BUILDING 502
Level 4, Room 502-401K
85 PARK RD
Auckland 1023
GRAFTON
New Zealand

 

Primary office location

M&HS BUILDING 505 - Bldg 505
Level 1, Room 101F
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links