Professor Paul James Donaldson
BSc, PhD (Otago)
Paul is the Director of the Molecular Vision Laboratory and is currently the Head of the School of Medical Sciences.
He obtained his PhD in field of epithelial transport from the Department of Physiology at the University of Otago in 1987, and this was followed by Post Doctoral Fellowships at Yale University and the University of Texas Medical Branch in Galveston. In 1990 he returned to New Zealand to take up a research position in the then Department of Cellular and Molecular Biology at The University of Auckland. This marked the start of a long and productive collaboration with Professor Joerg Kistler on the lens cataract research. In 1997 Dr Donaldson accepted a tenured position in the Department of Physiology at Auckland where he set up the Molecular Vision Laboratory. In 2004 he was promoted to Associate Professor and later in that year also became Head of Department.In 2008 he was appointed to the Chair in Optometry and Vision Science and assumed the leadership of the Department of Optometry and Vision Science and oversaw the transfer of the Department from the Faculy of Science to the Faculty of Medical and Health Sciences. In 2012 Paul was appointed as the Head of the School of Medical Sciences.
Paul built an international reputation as a vision research scientist. His research has been supported by numerous funding agencies including the Health Research Council, Wellcome Trust UK, Marsden Fund, Auckland Medical Research Foundation, Paykell Trust, Lotteries Health and the National Institutes of Health, USA.
He has been actively involved in the International Society of Eye Research (ISER) and the Association of Research in Vision and Ophthalmology for many years as a reviewer, keynote speaker and symposia organizer. He served as the Vice President (Pacific Rim) of ISER and is the Deputy Director of New Zealand National Eye Centre (NZ-NEC), a cross faculty center between Optometry and Vision Science, Ophthalmology and the Molecular Vision Laboratory.
Research | Current
The Molecular Vision Laboratory has extensive molecular and cellular expertise in the general field of membrane transport. Members of the laboratory utilize electrophysiology, imaging, biochemistry, proteomics, molecular biology, and computer modeling to determine how the properties of ion channels and transporters contribute to the integrative function of ocular tissues that comprise the front of the eye. Current research projects in the lens are focused on determining how the interaction of a variety of ion channels and transporters contribute to the maintenance of lens transparency.
Head of School School of Medical Sciences
Honorary Professor Department of Optometry and Vision Science
Honorary Professor, Department of Physiology
Associate Investigator Maurice Wilkins Centre for Biodiscovery,
Selected publications and creative works (Research Outputs)
- Anderson, D. M., Nye-Wood, M. G., Rose, K. L., Donaldson, P. J., Grey, A. C., & Schey, K. L. (2019). MALDI imaging mass spectrometry of β- and γ-crystallins in the ocular lens. Journal of mass spectrometry : JMS10.1002/jms.4473
Other University of Auckland co-authors: Gus Grey
- Chen, Y., Gao, J., Li, L., Sellitto, C., Mathias, R. T., Donaldson, P. J., & White, T. W. (2019). The Ciliary Muscle and Zonules of Zinn Modulate Lens Intracellular Hydrostatic Pressure Through Transient Receptor Potential Vanilloid Channels. Investigative ophthalmology & visual science, 60 (13), 4416-4424. 10.1167/iovs.19-27794
- Martis, R. M., Donaldson, P. J., Li, B., Middleditch, M., Kallingappa, P. K., & Lim, J. C. (2019). Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance. Histochemistry and cell biology, 152 (4), 293-310. 10.1007/s00418-019-01805-4
Other University of Auckland co-authors: Julie Lim, Prasanna Kallingappa
- Pan, X., Lie, A. L., White, T. W., Donaldson, P. J., & Vaghefi, E. (2019). Development of an in vivo magnetic resonance imaging and computer modelling platform to investigate the physiological optics of the crystalline lens. Biomedical optics express, 10 (9), 4462-4478. 10.1364/BOE.10.004462
Other University of Auckland co-authors: Alyssa Lie, Ehsan Vaghefi, Wilson Pan
- Nakazawa, Y., Donaldson, P. J., & Petrova, R. S. (2019). Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Experimental eye research, 18610.1016/j.exer.2019.107707
Other University of Auckland co-authors: Rosica Petrova
- Knight, L. J., Acosta, M. L., Martis, R., Donaldson, P. J., & Lim, J. C. (2019). The aging retina: early metabolic dysfunction in the retina of the xCT knockout mouse. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA. 28 April - 2 May 2019. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
Other University of Auckland co-authors: Monica Acosta, Julie Lim
- Gletten, R., Petrova, R., Donaldson, P. J., & Schey, K. L. (2019). Characterization of aquaporin-5 protein-protein interactions, subcellular localization, and phosphorylation in the ocular lens. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA. 28 April - 2 May 2019. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
- Donaldson, P. J. (2019). New views on the physiological biochemistry of the lens. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA. 28 April - 2 May 2019. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
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