Professor Paul James Donaldson
BSc, PhD (Otago)
Paul is the Director of the Molecular Vision Laboratory and is currently the Head of the School of Medical Sciences.
He obtained his PhD in field of epithelial transport from the Department of Physiology at the University of Otago in 1987, and this was followed by Post Doctoral Fellowships at Yale University and the University of Texas Medical Branch in Galveston. In 1990 he returned to New Zealand to take up a research position in the then Department of Cellular and Molecular Biology at The University of Auckland. This marked the start of a long and productive collaboration with Professor Joerg Kistler on the lens cataract research. In 1997 Dr Donaldson accepted a tenured position in the Department of Physiology at Auckland where he set up the Molecular Vision Laboratory. In 2004 he was promoted to Associate Professor and later in that year also became Head of Department.In 2008 he was appointed to the Chair in Optometry and Vision Science and assumed the leadership of the Department of Optometry and Vision Science and oversaw the transfer of the Department from the Faculy of Science to the Faculty of Medical and Health Sciences. In 2012 Paul was appointed as the Head of the School of Medical Sciences.
Paul built an international reputation as a vision research scientist. His research has been supported by numerous funding agencies including the Health Research Council, Wellcome Trust UK, Marsden Fund, Auckland Medical Research Foundation, Paykell Trust, Lotteries Health and the National Institutes of Health, USA.
He has been actively involved in the International Society of Eye Research (ISER) and the Association of Research in Vision and Ophthalmology for many years as a reviewer, keynote speaker and symposia organizer. He served as the Vice President (Pacific Rim) of ISER and is the Deputy Director of New Zealand National Eye Centre (NZ-NEC), a cross faculty center between Optometry and Vision Science, Ophthalmology and the Molecular Vision Laboratory.
Research | Current
The Molecular Vision Laboratory has extensive molecular and cellular expertise in the general field of membrane transport. Members of the laboratory utilize electrophysiology, imaging, biochemistry, proteomics, molecular biology, and computer modeling to determine how the properties of ion channels and transporters contribute to the integrative function of ocular tissues that comprise the front of the eye. Current research projects in the lens are focused on determining how the interaction of a variety of ion channels and transporters contribute to the maintenance of lens transparency.
Head of School School of Medical Sciences
Honorary Professor Department of Optometry and Vision Science
Honorary Professor, Department of Physiology
Associate Investigator Maurice Wilkins Centre for Biodiscovery,
Selected publications and creative works (Research Outputs)
- Zahraei, A., Guo, G., Perwick, R. D., Donaldson, P. J., Demarais, N. J., & Grey, A. C. (2020). Mapping glucose metabolites in the normal bovine lens: Evaluation and optimisation of a matrix-assisted laser desorption/ionisation imaging mass spectrometry method. Journal of mass spectrometry : JMS10.1002/jms.4666
Other University of Auckland co-authors: Gus Grey, George Guo
- Lim, J. C., Caballero Arredondo, M., Braakhuis, A. J., & Donaldson, P. J. (2020). Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract. Nutrients, 12 (10).10.3390/nu12103142
Other University of Auckland co-authors: Andrea Braakhuis
- Petrova, R. S., Bavana, N., Zhao, R., Schey, K. L., & Donaldson, P. J. (2020). Changes to Zonular Tension Alters the Subcellular Distribution of AQP5 in Regions of Influx and Efflux of Water in the Rat Lens. Investigative ophthalmology & visual science, 61 (11)10.1167/iovs.61.11.36
Other University of Auckland co-authors: Rosica Petrova
- Li, B., Kim, J.-Y., Martis, R. M., Donaldson, P. J., & Lim, J. C. (2020). Characterisation of Glutathione Export from Human Donor Lenses. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9 (8)10.1167/tvst.9.8.37
Other University of Auckland co-authors: Julie Lim
- Lie, A. L., Pan, X., White, T. W., Donaldson, P. J., & Vaghefi, E. (2020). Using the Lens Paradox to Optimize an In Vivo MRI-Based Optical Model of the Aging HumanCrystalline Lens. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 9 (8)10.1167/tvst.9.8.39
Other University of Auckland co-authors: Ehsan Vaghefi, Alyssa Lie, Wilson Pan
- Muir, E. R., Pan, X., Donaldson, P. J., Vaghefi, E., Jiang, Z., Sellitto, C., & White, T. W. (2020). Multi-parametric MRI of the physiology and optics of the in-vivo mouse lens. Magnetic resonance imaging, 70, 145-154. 10.1016/j.mri.2020.04.015
Other University of Auckland co-authors: Wilson Pan, Ehsan Vaghefi
- Lim, J. C., Li, I., Donaldson, P. J., & Poulsen, R. C. (2020). Shedding new light on the role of the lens in regulating circadian rhythms. Paper presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ELECTR NETWORK. 1 May - 7 May 2020. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. (pp. 2).
Other University of Auckland co-authors: Raewyn Poulsen, Julie Lim
- Lim, J. C., Grey, A. C., Zahraei, A., & Donaldson, P. J. (2020). Age-dependent changes in glutathione metabolism pathways in the lens: New insights into therapeutic strategies to prevent cataract formation-A review. Clinical & experimental ophthalmology10.1111/ceo.13801
Other University of Auckland co-authors: Julie Lim, Gus Grey
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