Dr Petr Tomek

BSc, MSc, RNDr

Research | Current

Immunomodulation for the treatment of cancer.

Discovery and development of small-molecule inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) for cancer therapy.

Areas of expertise

Analytical chemistry, biochemistry, molecular biology. microbiology, biotechnology

Selected publications and creative works (Research Outputs)

  • Tomek, P., Palmer, B. D., Flanagan, J. U., Sun, C., Raven, E. L., & Ching, L. M. (2017). Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. European Journal of Medicinal Chemistry, 126, 983-996. 10.1016/j.ejmech.2016.12.029
    Other University of Auckland co-authors: Lai-Ming Ching, Brian Palmer, Jack Flanagan
  • Tomek, P., Hallermayr, A., Print, C. G., Sattlegger, E., & Ching, L. (2016). The impact of IMPACT on cancer cell survival during tryptophan deprivation. Paper presented at New Zealand Society for Oncology conference 2016, Palmerston North, New Zealand. 25 October - 26 October 2016.
    Other University of Auckland co-authors: Cris Print, Lai-Ming Ching
  • Tomek, P., Palmer, B. D., Kendall, J. D., Flanagan, J. U., & Ching, L.-M. (2015). Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine. Biochimica et biophysica acta, 1850 (9), 1772-1780. 10.1016/j.bbagen.2015.04.007
    Other University of Auckland co-authors: Jack Flanagan, Brian Palmer, Jackie Kendall, Lai-Ming Ching
  • Ching, L.-M., Palmer, B. D., Tomek, P., Flanagan, J. U., & Henare, K. (2015). Abstract 4469: A novel class of inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) with potential for the treatment of cancer. Cancer Research. 10.1158/1538-7445.AM2015-4469
    Other University of Auckland co-authors: Lai-Ming Ching, Brian Palmer, Kimi Henare
  • Tomek, P., Hrouzek, P., Kuzma, M., Sýkora J, Fiser, R., Cerný J, ... Hof, M. (2015). Cytotoxic Lipopeptide Muscotoxin A, Isolated from Soil Cyanobacterium Desmonostoc muscorum, Permeabilizes Phospholipid Membranes by Reducing Their Fluidity. Chemical research in toxicology, 28 (2), 216-224. 10.1021/tx500382b
  • Tomek, P., Palmer, B. D., Flanagan, J. U., & Ching, L. (2014). Significance of serine-167 and cysteine-129 residues in the active site of the immune-suppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) for the binding of novel inhibitors. Paper presented at 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, European Org Res & Treatment Canc, Barcelona, SPAIN. 18 November - 21 November 2014. EUROPEAN JOURNAL OF CANCER. (pp. 1).
    Other University of Auckland co-authors: Lai-Ming Ching, Brian Palmer
  • Ching, L.-M., Henare, K., Tijono, S., & Tomek, P. (2014). The role of two NODs and a STING in the tale of DMXAA. Paper presented at New Zealand Society for Oncology Conference: Oncology in New Zealand; current and future challenges, Tauranga, New Zealand. 21 October - 23 October 2014.
    URL: http://hdl.handle.net/2292/25223
    Other University of Auckland co-authors: Lai-Ming Ching, Kimi Henare, Sofian Tijono
  • Tomek, P., Palmer, B. D., Flanagan, J. U., & Ching, L.-M. (2014). Development of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) for cancer therapy: New, sensitive assay for high throughput screening of compound libraries for novel small molecule inhibitors of IDO1. Paper presented at New Zealand Society for Oncology Conference: Oncology in New Zealand; current and future challenges, Tauranga, New Zealand. 21 October - 23 October 2014.
    URL: http://hdl.handle.net/2292/25215
    Other University of Auckland co-authors: Lai-Ming Ching, Brian Palmer