Dr Petr Tomek

BSc, MSc, RNDr, PhD

Research | Current

Current research projects:

  • Discovery and development of novel small-molecule inhibitors to the immunosuppressive enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) for cancer therapy.
  • Resistance mechanisms of cancer cells to stress situations encountered in the tumour nicroenvironment such as nutrient deprivation
  • The role of Imprinted and Ancient gene (IMPACT) in the resistance of cancer cells to amino acid deficiency

Areas of expertise

Cancer cell biology, molecular biology, biochemistry, analytical chemistry, genome editing, cancer drug discovery, high-throughput research technologies, tumour biology, immuno-oncology, bioinformatics

Selected publications and creative works (Research Outputs)

  • Tomek, P., Gore, S. K., Potts, C. L., Print, C. G., Black, M. A., Hallermayr, A., ... Ching, L. M. (2018). Imprinted and ancient gene: A potential mediator of cancer cell survival during tryptophan deprivation. Cell Communication and Signaling, 16 (1).10.1186/s12964-018-0301-7
    Other University of Auckland co-authors: Cristin Print, Lai-Ming Ching
  • Tomek, P., Palmer, B. D., Flanagan, J. U., Sun, C., Raven, E. L., & Ching, L. M. (2017). Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. European Journal of Medicinal Chemistry, 126, 983-996. 10.1016/j.ejmech.2016.12.029
    URL: http://hdl.handle.net/2292/44445
    Other University of Auckland co-authors: Lai-Ming Ching, Brian Palmer, Jack Flanagan
  • Tomek, P., Hallermayr, A., Print, C. G., Sattlegger, E., & Ching, L. (2016). The impact of IMPACT on cancer cell survival during tryptophan deprivation. Paper presented at New Zealand Society for Oncology conference 2016, Palmerston North, New Zealand. 25 October - 26 October 2016.
    Other University of Auckland co-authors: Cristin Print, Lai-Ming Ching
  • Tomek, P., Palmer, B. D., Kendall, J. D., Flanagan, J. U., & Ching, L.-M. (2015). Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine. Biochimica et biophysica acta, 1850 (9), 1772-1780. 10.1016/j.bbagen.2015.04.007
    Other University of Auckland co-authors: Jack Flanagan, Brian Palmer, Lai-Ming Ching
  • Ching, L. M., Palmer, B. D., Tomek, P., Flanagan, J. U., & Henare, K. (2015). A novel class of inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) with potential for the treatment of cancer. Paper presented at AACR Annual Meeting 2015, Philadelphia, Pennsylvania. 18 April - 22 April 2015. Cancer research, volume 75, issue 15 Supplement: Proceedings: AACR 106th Annual Meeting 2015. 10.1158/1538-7445.AM2015-4469
    Other University of Auckland co-authors: Lai-Ming Ching, Brian Palmer, Kimi Henare
  • Tomek, P., Hrouzek, P., Kuzma, M., Sýkora J, Fiser, R., Cerný J, ... Hof, M. (2015). Cytotoxic lipopeptide muscotoxin A, isolated from soil cyanobacterium desmonostoc muscorum, permeabilizes phospholipid membranes by reducing their fluidity. Chemical Research in Toxicology, 28 (2), 216-224. 10.1021/tx500382b
  • Tomek, P., Palmer, B. D., Flanagan, J. U., & Ching, L. (2014). Significance of serine-167 and cysteine-129 residues in the active site of the immune-suppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) for the binding of novel inhibitors. Paper presented at 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona, Spain. 1 November - 1 November 2014. European Journal of Cancer. 10.1016/S0959-8049(14)70399-5
    Other University of Auckland co-authors: Lai-Ming Ching, Brian Palmer
  • Ching, L.-M., Henare, K., Tijono, S., & Tomek, P. (2014). The role of two NODs and a STING in the tale of DMXAA. Paper presented at New Zealand Society for Oncology Conference: Oncology in New Zealand; current and future challenges, Tauranga, New Zealand. 21 October - 23 October 2014.
    URL: http://hdl.handle.net/2292/25223
    Other University of Auckland co-authors: Lai-Ming Ching, Kimi Henare, Sofian Tijono

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level B, Room B01
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand