Mr Praveen George Vadakkedath

B.Tech, M.Tech

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Doctoral Candidate - Doctor of Philosophy

Biography

Before pursuing my graduate studies, I attained Bachelor of Technology (B.Tech) in Biotechnology from Karunya University, India. Infact my interest towards research began during bachelor thesis work. The project titled " Synthesis of a novel protein from the non-coding region of E.coli genome and its nuclease activity. The work involved purification of protein as well as testing its nuclease activity. 

Further, I have obtained my Master of Technology (M.Tech) in Nanotechnology from Amity University, India. During Master thesis, I have done two projects through which I have gained skills of synthesis of nanomaterials as well as its characterization. Thefirst project was on " synthesis of gold nano rods and its application in heavy metal sensing" where as the second project was on " Synthesis of graphene oxide nanoparticles and its potential application in photocatalysis and water purification". 

Since March 2016, I am a doctoral student at the University of Auckland till present.

 

 

Research | Current

My research interest lies in Biophysical chemistry and Bionanotechnology.

The first project involved studying conformational changes, kinetics and thermal stability of PHD2 enzyme upon interactions with CODD or NODD substrates of HIF-α. This work is comprised of PHD2 DNA cloning along with protein expression and its purification as well as synthesis and purification of CODD or NODD peptides. In terms of characterization, I have gained skills in sample preparation, performing experiment and analysis of Small angle X-ray scattering (SAXS)

My current work involves creating and controlling dynamic and reversible bionanostructures of different physical dimensions and different shapes using peptide, boronic acid as building blocks  

Moreover, I am also interested in different characterization techniques especially in optics, instrumentation and sample preparation and  data analysis. Some of the interesting techniques I use for my studies are Light scattering, Small angle X-ray scattering and Small angle neutron scattering, Atomic force microscopy, negative stain and cryo Transmission electron microscopy among others. 

Teaching | Current

Graduate Teaching Assistant (Grade III) - Chem 100, Chem110

Distinctions/Honours

  • PhD Scholarship 2016 - 2019, The MacDiarmid institute of advanced materials and nanotechnology, Wellington, New Zealand
  • AINSE Travel Scholarship - AINSE, Australia
  • MESA Travel Scholarship  - The MacDiarmid emerging scientists association, Wellington, New Zealand

Areas of expertise

  • Biophysical chemistry
  • Bionanotechnology - Reversible and tuneable nanostructures
  • Biomolecular Small angle X-ray and neutron scattering (SAXS, SANS)
  • Dynamic light scattering (DLS)
  • Light microscopy, Fluorescence and confocal microscopy
  • Atomic force microscopy (AFM)and negative staining Transmission electron microscopy (TEM)of peptide- protein complexes
  • Circular dichroism (CD) spectroscopy of peptides and proteins
  • Isothermal titration calorimetry (ITC) of small molecules, peptides and proteins
  • NMR spectroscopy of small molecules and peptides 

Committees/Professional groups/Services

Memberships

  • Member, The MacDiarmid institute of advanced materials and nanotechnology, New Zealand
  • Student member,  International society of Photonics and Optics (SPIE), USA
  • Member, MacDiarmid Emerging Scientists Association (MESA)
  • Member, Postgraduate Students Association (PGSA), University of Auckland
  • Board member representative, Faculty of science, PGSA, University of Auckland
  • Communications & Marketing Team role, PGSA, University of Auckland

 

Science Outreach Programmes

  • Student Volunteer - Korero with Scientists, MacDiarmid institute & University of Auckland, Auckland, 2016
  • Volunteer - UNESCO International day of light (Historic science fair for school students), SPIE student chapter, Auckland, 2018
  • Exhibitor - Space and Science festival, The MacDiarmid institute, Wellington, 2018
  • Participant - Bootcamp on science of surfaces, The MacDiarmid institute and MESA, Wanaka, 2018
  • Volunteer - Northland science road show, SPIE student chapter, Northland, 2018

 

 

Selected publications and creative works (Research Outputs)

Identifiers

Contact details

Primary office location

SCIENCE CENTRE 302 - Bldg 302
Level 9, Room 913
23 SYMONDS ST
AUCKLAND CENTRAL
AUCKLAND 1010
New Zealand

Social links

Web links