Mr Rohit Bisht

B.Pharm., M.Pharm (Pharmaceutics), PGD (Pharma Regulatory Affairs)

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Doctoral Candidate - Doctor of Philosophy

Biography

An enthusiastic, adaptive and fast-learning person with a broad and acute interest in the development of new drug delivery systems, I particularly enjoy working with scientists from same and different disciplines to develop new skills and solve new challenges.

 

Research | Current

-M.Pharm. research: Formulation and evaluation of crosslinked gelatin patch for intrastromal delivery of Natamycin: An in vitro, ex vivo and in vivo evaluation using LC-MS/MS. Department of Ocular Phramacology, Pharmacy and Toxicity, All India Institute of Medical Sciences (A.I.I.M.S), New Delhi, India.

  • Intracorneal Implant
  • Transcorneal penetration studies.
  • HPLC and LC-MS/MS.
  • Transcorneal penetration studies in rabbits as an experimental model.

- Visiting Research Scholar- Prof. Ashim Kumar Mitra's Lab. University of Missoure-Kansas City, Kansas City, USA.

Research: Ex Vivo Investigation of Ocular Tissue Distribution Following Intravitreal Administration of Connexin43 Mimetic Peptide Using the Microdialysis Technique and LC-MS/MS (Published in DDTR)

Technical skill acquired:

  • Intravitral microdialysis technique.
  • Development of Tri- and Penta block polymers and temperature-responsive in situ forming injectable implants.
  • LC-MS studies.
  • Ex-vivo ocular tissue distribution studies.
  • Development of an ex-vivo intraocular models for evaluation of intravitreal ocular formulations.

-PhD research

Nanoparticle-loaded light-responsive in situ forming injectable implants for effective drug delivery to the posterior segment of the eye.

Distinctions/Honours

  • Invited at AAPS President's (Dr. Greg Amidon) reception, Ellie Caulkins Opera House, Denver, USA-14 Nov 2016.
  • 2016-Ocular Drug Delivery & Disposition Focus Group Research Award-American Association of  Pharmaceutical Scientist (AAPS), USA
  • Patent- Apparatus for eyeball studies and methods of use thereof-2015.
  • Univertsity of Auckland International Doctoral Scholarship-2015
  • Buchanan Ocular Therapeutic Unit (BOTU) Sholarship-2014
  • Faculty of Medical and Health Sciences (FMHS)-PGSA-Travel Grant-2015
  • Sir Jhon Cambell Medical Trust- Travel Grant-2015
  • Research trainee-Department of Ocular Pharmacology, Pharmacy and Toxicology, Dr. R.P.Center for Ophthalmic Sciences, All India Institute of Medical Sciences (A.I.I.M.S), New Delhi, INDIA-2009-2010
  • Qualified G.A.T.E (Graduate Aptitude Test in Engineering) conducted by IIT-K (Indian Institute of Technology) in 2007.
  • GATE Research Fellowship-2008-2010. Ministry of Human Resourse, All India Council of Technical Education (AICTE), Govt. of India.
  • Achived Masters Degree (M.Pharm.) with Distinction (University Rank holder).

Areas of expertise

  • Ocular Implants (Transcorneal and Intravitreal)
  • Nanomedicenes
  • In-situ gels
  • Chronomodulated/ Pulsatile drug delivery systems
  • Biomimetic systems
  • Ocular Pharmacikinetic modelling.
  • Microparticulate drug delivery system
  • Toxicity studies (MTT, SRB & Zebrafish Embryo Toxicity (ZET) Model)
  • QbD Formulation using different statistical models (ANN, RSM, BBD, CCDetc)
  • Transcorneal penetration studies (Ex-vivo & In-vivo)
  • Light sensitive drug delivery systems.
  • In-silico models (Drug-polymer interaction).
  • Cassette dosing for pharmacokinetic screening.
  • Microdialyisis technique for intravitreal pharmacokinetic investigation.
  • Transdermal drug delivery systems (films, gels..)
  • HPLC
  • LC-MS
  • Stability studies-Accelerated and forced stability studies.

Committees/Professional groups/Services

  • Association of Pharmaceutical Teachers of India (APTI)-Life Member
  • Post Graduate Student Association (PGSA), University of Auckland-Member
  • American Association of Pharmaceutical Scientists (AAPS)-Member
  • American Chemical Society (ACS)-Member
  • British Society for Nanomedicine (BSN)-Scientific Member
  • Official online advisor- American Chemical Society (ACS) Insight Lab.
  • Scientific Member- European Society of  Biochemical Engineering Sciences (ESBES)

         Reviewer:

  1. American Journal of Nanomaterial
  2. Drug Delivery and Transitional Research (Controlled Release Society).
  3. Journal of Pharmacy Research
  4. Journal of Pharmaceutical Science and Pharmacy, Canadian Society of Pharmaceutical Sciences
  5. Science Publishing Group
  6. Benthem journals ( Current HIV, Current drug delivery etc).................
  7. International Journal of Ophthalmology (Dove press)

 

 

Selected publications and creative works (Research Outputs)

  • Bisht, R., Jaiswal, J., Oliver, V., Eurtivong, C., Reynisson, J., & Rupenthal, I. D. (2017). Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery. Journal of Drug Delivery Science and Technology, 40 (August), 142-156. 10.1016/j.jddst.2017.06.006
    Other University of Auckland co-authors: Jagdish Jaiswal, Verity Oliver, Chatchakorn Eurtivong, Johannes Reynisson, Ilva Rupenthal
  • Bisht, R., Rupenthal, I. D., Sreebhavan, S., & Jaiswal, J. (2017). Development of a novel stability indicating RP-HPLC method for quantification of Connexin43 mimetic peptide and determination of its degradation kinetics in biological fluids. Journal of Pharmaceutical Analysis10.1016/j.jpha.2017.06.008
    Other University of Auckland co-authors: Ilva Rupenthal, Sree Sreebhavan, Jagdish Jaiswal
  • Bisht, R., Jaiswal, J. K., & Rupenthal, I. D. (2017). Nanoparticle-loaded biodegradable light-responsive in situ forming injectable implants for effective peptide delivery to the posterior segment of the eye. Medical hypotheses, 103, 5-9. 10.1016/j.mehy.2017.03.033
    Other University of Auckland co-authors: Jagdish Jaiswal, Ilva Rupenthal
  • Bisht, R., Mandal, A., JAISWAL, J. K., & RUPENTHAL, I. (2017). Nanotechnology Enhances Drug Delivery to the Back of the Eye. USA: Advance Science News. Related URL.
    Other University of Auckland co-authors: Jagdish Jaiswal, Ilva Rupenthal
  • Bisht, R., Mandal, A., Jaiswal, J. K., & Rupenthal, I. D. (2017). Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology10.1002/wnan.1473
    Other University of Auckland co-authors: Jagdish Jaiswal, Ilva Rupenthal
  • Mandal, A., Bisht, R., Rupenthal, I. D., & Mitra, A. K. (2017). Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies. Journal of controlled release : official journal of the Controlled Release Society, 248, 96-116. 10.1016/j.jconrel.2017.01.012
    Other University of Auckland co-authors: Ilva Rupenthal
  • Bisht, R. (2017). PLGA nanoparticle-loaded light-responsive insitu forming injectable implants for effective drug delivery to the back of the eye The University of Auckland. ResearchSpace@Auckland.
  • Bisht, R., Mandal, A., Rupenthal, I. D., & Mitra, A. K. (2016). Ex vivo investigation of ocular tissue distribution following intravitreal administration of connexin43 mimetic peptide using the microdialysis technique and LC-MS/MS. Drug Deliv Transl Res, 6 (6), 763-770. 10.1007/s13346-016-0308-9
    Other University of Auckland co-authors: Ilva Rupenthal

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0220937361

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9:00 am-6:00 pm

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