Professor Rod Dunbar

Research | Current

  • Cancer vaccines
  • Cancer therapy
  • Cellular immunology

Professor Rod Dunbar holds both a medical degree (MBChB) and a PhD from the University of Otago in New Zealand. He spent 6 years as a post-doctoral research fellow in human immunology at the University of Oxford, before returning to New Zealand in 2002 under a Wellcome Trust International Senior Research Fellowship. In 2008 he was appointed the Director of the Maurice Wilkins Centre, a national Centre of Research Excellence that promotes a multi-disciplinary approach to the discovery of new medicines and vaccines. Since 2009 he has also co-directed a programme within the University of Auckland to accelerate its research related to human therapeutics (the Biopharma Thematic Research Initiative).

Rod's lab has a primary focus on human cellular immunology, especially understanding how T cell responses to tumours arise and how these T cell responses can be stimulated in cancer therapy. The lab has particular expertise in the use of flow cytometry and immunofluorescence microscopy to study T cells and antigen-presenting cells in human tissues, and in analysing the function of these cells in primary cell culture models. These techniques are also employed by the lab to characterise mesenchymal stem cells in human tissues, and examine their role in human disease and their potential in cell therapy and tissue engineering. Rod's lab interacts with a wide collaborative network with particular strengths in organic and medicinal chemistry, tissue imaging, and computer modelling.

Areas of expertise

Proteomics and Biomedicine

Selected publications and creative works (Research Outputs)

  • Gane, E., Verdon, D. J., Brooks, A. E., Gaggar, A., Nguyen, A. H., Subramanian, G. M., ... Dunbar, P. R. (2019). Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study. Journal of hepatology, 71 (5), 900-907. 10.1016/j.jhep.2019.06.028
    Other University of Auckland co-authors: Anna Brooks
  • Loef, E. J., Brooks, A. E. S., Lorenz, N., Birch, N. P., & Dunbar, P. R. (2019). Neuroserpin regulates human T cell-T cell interactions and proliferation through inhibition of tissue plasminogen activator. Journal of leukocyte biology10.1002/jlb.2a1019-098rr
    Other University of Auckland co-authors: Evert Loef, Anna Brooks, Natalie Lorenz
  • Brooks, A. E., Verdon, D., Eom, J., Ng, J., Steemson, J., Lau, A. H., ... Poonia, B. (2019). PERIPHERAL IMMUNE RESPONSES TO TOLL-LIKE RECEPTOR 8 AGONIST GS-9688 IN PATIENTS WITH CHRONIC HEPATITIS B. Paper presented at Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Boston, MA. 8 November - 12 November 2019. HEPATOLOGY. (pp. 2).
    Other University of Auckland co-authors: Anna Brooks
  • Brooks, A. E., Lehnert, K., & Dunbar, P. R. (2019). INTEGRATION OF SINGLE CELL TECHNOLOGIES REVEALS HUMAN ADIPOSE TISSUE-DERIVED STROMAL CELLS ARE MORE HETEROGENEOUS THAN PREVIOUSLY APPRECIATED. CYTOTHERAPY. (pp. 1). 10.1016/j.jcyt.2019.04.032
    Other University of Auckland co-authors: Anna Brooks
  • Lu, B. L., Williams, G. M., Verdon, D. J., Dunbar, P. R., & Brimble, M. A. (2019). Synthesis and Evaluation of Novel TLR2 Agonists as Potential Adjuvants for Cancer Vaccines. Journal of Medicinal Chemistry10.1021/acs.jmedchem.9b01044
    URL: http://hdl.handle.net/2292/48666
    Other University of Auckland co-authors: Benjamin Lu, Geoffrey Williams, Margaret Brimble
  • Schwabe, C., Rosenstock, B., Doan, T., Hamilton, P., Dunbar, P. R., Eleftheraki, A. G., ... Padula, S. J. (2018). Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of BI 655064, an Antagonistic Anti-CD40 Antibody, in Healthy Subjects: A Potential Novel Treatment for Autoimmune Diseases. Journal of clinical pharmacology, 58 (12), 1566-1577. 10.1002/jcph.1278
  • Meidinger, S., Brooks, A., Lehnert, K., Feisst, V., Locke, M., & Dunbar, R. (2018). CD26+FAP+ fibroblasts increase ECM expression in keloid scarring. Paper presented at International Investigative Dermatology (IID) Meeting, Orlando, FL. 16 May - 19 May 2018. JOURNAL OF INVESTIGATIVE DERMATOLOGY. (pp. 1).
    Other University of Auckland co-authors: Sarah Meidinger, Anna Brooks, Vaughan Feisst
  • Nie, T., Zhao, S., Mao, L., Yang, Y., Sun, W., Lin, X., ... Li, P. (2018). The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity. British journal of pharmacology, 175 (9), 1439-1450. 10.1111/bph.14139

Identifiers

Contact details

Primary office location

THOMAS BUILDING EXTENSION - Bldg 110N
3A SYMONDS ST
AUCKLAND CENTRAL
AUCKLAND 1010
New Zealand

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