Professor Rod Dunbar

Research | Current

  • Cancer vaccines
  • Cancer therapy
  • Cellular immunology

Professor Rod Dunbar holds both a medical degree (MBChB) and a PhD from the University of Otago in New Zealand. He spent 6 years as a post-doctoral research fellow in human immunology at the University of Oxford, before returning to New Zealand in 2002 under a Wellcome Trust International Senior Research Fellowship. In 2008 he was appointed the Director of the Maurice Wilkins Centre, a national Centre of Research Excellence that promotes a multi-disciplinary approach to the discovery of new medicines and vaccines. Since 2009 he has also co-directed a programme within the University of Auckland to accelerate its research related to human therapeutics (the Biopharma Thematic Research Initiative).

Rod's lab has a primary focus on human cellular immunology, especially understanding how T cell responses to tumours arise and how these T cell responses can be stimulated in cancer therapy. The lab has particular expertise in the use of flow cytometry and immunofluorescence microscopy to study T cells and antigen-presenting cells in human tissues, and in analysing the function of these cells in primary cell culture models. These techniques are also employed by the lab to characterise mesenchymal stem cells in human tissues, and examine their role in human disease and their potential in cell therapy and tissue engineering. Rod's lab interacts with a wide collaborative network with particular strengths in organic and medicinal chemistry, tissue imaging, and computer modelling.

Areas of expertise

Proteomics and Biomedicine

Selected publications and creative works (Research Outputs)

  • Brooks, A. E., Boss, A. L., Lehnert, K., & Dunbar, P. R. (2020). Dissecting adipose tissue derived mesenchymal stromal cell heterogeneity using single cell rna sequencing and multiparameter spectral flow cytometry. CYTOTHERAPY. (pp. 2).
    Other University of Auckland co-authors: Anna Brooks
  • Cebon, J. S., Gore, M., Thompson, J. F., Davis, I. D., McArthur, G. A., Walpole, E., ... MacGregor, D. (2020). Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma. Journal for immunotherapy of cancer, 8 (1).10.1136/jitc-2019-000410
    Other University of Auckland co-authors: Michael Findlay, Margaret Brimble
  • Park, S., Brooks, A., Chen, C.-J., & Dunbar, R. (2020). Molecular characteristics of tumor-associated macrophages in human melanoma metastases.. CANCER IMMUNOLOGY RESEARCH. (pp. 2).
    Other University of Auckland co-authors: Anna Brooks
  • Brooks, A. E. S., Iminitoff, M., Williams, E., Damani, T., Jackson-Patel, V., Fan, V., ... Sheppard, H. M. (2020). Ex Vivo Human Adipose Tissue Derived Mesenchymal Stromal Cells (ASC) Are a Heterogeneous Population That Demonstrate Rapid Culture-Induced Changes. FRONTIERS IN PHARMACOLOGY, 1010.3389/fphar.2019.01695
    Other University of Auckland co-authors: Anna Brooks, Vicky Fan, Vaughan Feisst, Hilary Sheppard
  • Cameron, A. J., Davison, E. K., An, C., Stubbing, L. A., Dunbar, P. R., Harris, P. W. R., & Brimble, M. A. (2020). Synthesis and SAR Analysis of Lipovelutibols B and D and Their Lipid Analogues. The Journal of organic chemistry, 85 (3), 1401-1406. 10.1021/acs.joc.9b02348
    Other University of Auckland co-authors: Margaret Brimble, Alan Cameron, Louise Stubbing, Emma Davison, Paul Harris
  • Loef, E. J., Brooks, A. E. S., Lorenz, N., Birch, N. P., & Dunbar, P. R. (2020). Neuroserpin regulates human T cell-T cell interactions and proliferation through inhibition of tissue plasminogen activator. Journal of leukocyte biology, 107 (1), 145-158. 10.1002/jlb.2a1019-098rr
    URL: http://hdl.handle.net/2292/51459
    Other University of Auckland co-authors: Evert Loef, Anna Brooks, Natalie Lorenz
  • Kelch, I. D., Bogle, G., Sands, G. B., Phillips, A. R. J., LeGrice, I. J., & Dunbar, P. R. (2019). High-resolution 3D imaging and topological mapping of the lymph node conduit system. PLoS biology, 17 (12)10.1371/journal.pbio.3000486
    Other University of Auckland co-authors: Anthony Phillips, Inken Kelch, Gib Bogle, Gregory Sands, Ian LeGrice
  • Gane, E., Verdon, D. J., Brooks, A. E., Gaggar, A., Nguyen, A. H., Subramanian, G. M., ... Dunbar, P. R. (2019). Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study. Journal of hepatology, 71 (5), 900-907. 10.1016/j.jhep.2019.06.028
    Other University of Auckland co-authors: Anna Brooks

Identifiers

Contact details

Primary office location

THOMAS BUILDING EXTENSION - Bldg 110N
Level 2, Room 2010
3A SYMONDS ST
AUCKLAND CENTRAL
AUCKLAND 1010
New Zealand

Web links