Dr Jagir Hussan

BE Coimbatore IT, PhD

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Research Fellow

Biography

Jagir Hussan has an engineering degree from the Coimbatore Institute of Technology, India and a PhD in Bioengineering from the University of Auckland, New Zealand. Prior to his PhD studies, he worked for the IBM Corporation, specialising in high performance computing solutions for biology, finance and multimedia intelligence. His PhD was in cardiac electrophysiology, specifically focused towards understanding the role of ion-channels in cardiac arrhythmias using first principles.

He is involved in projects ranging from modelling skin-textile interaction, to developing models of cardiac looping. The core theme underlying these investigations is on developing frameworks and analysis techniques to investigate multiscale phenomena that commonly arise in biology.

Through funding from the Aotearoa Foundation, he is currently developing a model of the neuroendocrine system of human skin and its interaction with the skin resident microbiome. Specifically, he is interested in how the interaction architecture evolves, potentiates and modulates the activation of mechanical, chemical and electrical signalling pathways and control programs. A targeted outcome is to determine the mechanisms underlying disease phenotypes.

Current active areas of research include:

  • Non-equilibrium thermodynamics,
  • Quasi-conformal analysis,
  • Mechanobiology,
  • Human microbiome and the Skin,
  • Endocrine systems modelling.

Research | Current

 

Host Microbiome Interactions

Modelling host-microbiome interactions in humans and animals.  Learn more about this research at the ABI's Animal and Microbiome Research project page. Key themes guiding current research are summarised below:

Does a low Selenium diet under high UV exposure lead to skin infections?

Serious skin infections pose a significant risk to children, elderly and deprived populations. It is a complex disease and arises from the intimate interactions between the skin, immune system and the skin-microbiome. Recent studies have indicated that westernised diet can be a factor. Selenium, a mineral low in NZ soils, has been shown to be important in skin protection against UV induced damages. We are investigating whether a westernised diet with low selenium and high UV exposure could explain the high incidence of eczema and related skin disorders in NZ children.

Multiscale model of cutaneous endocrine system

Human skin produces, activates or inactivates numerous hormones. Some of these are important for normal skin function but some also contribute to the functioning of the entire human organism. Being the primary barrier between the environment and the internal milieu it not only protect from environmental assaults but it plays a vital role in thermoregulation, sensing and feedback. There is increasing evidence that this sensing and feedback occurs not only through the cutaneous nervous system, but also through the cutaneous endocrine system. Interactions with the resident skin-microbiome also plays a major role. Through funding from the Aotearoa Foundation, we are developing models of the cutaneous endocrine system and its interactions with skin-microbiome. The physical systems are represented using Port-Hamiltonians and are interconnected to form larger ensembles.

Postgraduate supervision

PhD:

Hashem Yousefi, University of Auckland. How does the heart grow?

Mary Familusi, University of Cape Town. Clinical Study and Mathematical Modelling of Rheumatic Heart Disease.

Areas of expertise

  • Computational Physiology
  • Functional Genomics
  • Numerical Analysis
  • Nonlinear elasticity
  • Quasiconformal Analysis
  • High performance computing
  • Networked Dynamical systems

Selected publications and creative works (Research Outputs)

Identifiers

Contact details

Primary office location

AUCKLAND BIOENGINEERING HOUSE - Bldg 439
Level 6, Room 601
70 SYMONDS ST
GRAFTON
AUCKLAND 1010
New Zealand

Web links