Dr Ries James Langley

MSc, PhD (Molecular Medicine)

Research | Current

Staphylococcus aureus is a major infectious organism.  It causes higher rates of disease in New Zealand than other developed countries and is a major cause of skin and soft tissue infection, bacteraemia, and endocarditis.  Of considerable concern are the high rates of disease seen in our children and the sociodemographic disparities associated with infection.  The ability to gain resistance to antibiotics, and the many virulence factors it produces, are what makes S. aureus a formidable pathogen. Though many virulence factors have been identified, genome analysis reveals numerous open reading frames of unknown function that are likely to be virulence factors.  I am interested in identifying undescribed virulence factors, discovering the mechanisms by which they contribute to staphylococcal disease, and investigating the targeting of their activities as novel anti-staphylococcal therapies.

Teaching | Current

MEDSCI 314: Immunology

MEDSCI 708: Advanced Immunology

Postgraduate supervision

I am interested in supervising students at the Honours, Masters, and PhD levels.

Responsibilities

Councillor for the NZ Branch of the Australasian Society of Immunology

http://www.immunology.org.au/regional-branches/new-zealand-branch/

Areas of expertise

Infection and immunity

Host-pathogen interaction

Staphylococcus aureus virulence

Bacterial immune evasion

Molecular biology

 

Selected publications and creative works (Research Outputs)

  • Langley, R., Ting, Y. T., Radcliff, F., Clow, F., Young, P., Choi, J., ... Fraser, J. (2016). Functional and structural insights into a unique SElXy staphylococcal superantigen. Paper presented at ICI 2016: International Congress of Immunology, Melbourne, Australia. 21 August - 26 August 2016. European Journal of Immunology: Abstracts of ICI 2016.
    Other University of Auckland co-authors: Fiona Radcliff
  • Langley, R. J., & Fraser, J. D. (2013). The Staphylococcal Superantigen-Like Toxins. In T. Proft (Ed.) Bacterial Toxins: Genetics, Cellular Biology and Practical Applications (pp. 129-156). Norwich: Caister Academic Press.
  • Langley, R. J., Choi, J., Radcliff, J. F., & Fraser, J. D. (30/7/2013). In vivo analysis of Staphylococcal Superantigen-Like (SSL) protein production during infection. Poster presented at 13th Gordon Conference on Staphylococcal Diseases, Waterville Valley Resort, New Hampshire, USA. Related URL.
  • Hermans, S. J., Baker, H. M., Sequeira, R. P., Langley, R. J., Baker, E. N., & Fraser, J. D. (2012). Structural and functional properties of staphylococcal superantigen-like protein 4. Infection and Immunity, 80 (11), 4004-4013. 10.1128/IAI.00764-12
    Other University of Auckland co-authors: John Fraser
  • Deng, L., Langley, R. J., Wang, Q., Topalian, S. L., & Mariuzza, R. A. (2012). Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3. Proceedings of the National Academy of Sciences, Online10.1073/pnas.1207186109
  • Langley, R. J., & Renno, T. (2011). Superantigens. Encyclopedia of Life Sciences (eLS). John Wiley & Sons Ltd. 10.1002/9780470015902.a0001216.pub2
  • Patel, D., Wines, B. D., Langley, R. J., & Fraser, J. D. (2010). Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain. J Immunol, 184 (11), 6283-6292. 10.4049/jimmunol.0903311
    URL: http://hdl.handle.net/2292/17367
    Other University of Auckland co-authors: John Fraser
  • Langley, R., Patel, D., Jackson, N., Clow, F., & Fraser, J. D. (2010). Staphylococcal superantigen super-domains in immune evasion. Crit Rev Immunol, 30 (2), 149-165. Related URL.
    URL: http://hdl.handle.net/2292/7842
    Other University of Auckland co-authors: John Fraser

Identifiers

Contact details

Primary office location

M&HS BUILDING 502 - Bldg 502
Level 3, Room 301
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links