Dr Ravi Telang

BVSc & AH, MVSc, PhD

Research | Current

Hearing loss in young adults and old people is emerging as one of the largest disability groups worldwide. In New Zealand and Australia it affects 1 in 6 people, a prevalence expected to rise to 1 in 4 by 2050. Hearing loss occurs predominately through injury or disease of the inner ear. Unfortunately, hair cells and neurons do not regenerate following injury. In the absence of treatments for the injury the only option for many is a hearing aid or cochlear implant in profundly deaf subjects.

Cochlear implants success is marred by the inflammatory response in inner ear due to surgical trauma. My lab is working on improving the outcome of cochlear implants through the novel use of MS-PGA nanoparticles as drug carriers. We are investigating the potential use of adenosine receptor agonists and neurotrophins to reduce hair cell and neural injury following implantation in animals with residual hearing.

Our lab has done some interesting research on following aspects of auditory neuroscience in past:

  • Age related changes in cochlear purinergic signalling, and the modulatory role of ATP
  • Role of purinergic P2X2 receptors in noise stress handling mechanisms of cochlea
  • Ionic homeostasis in inner ear, as influenced by ageing and noise trauma
  • Adaptive regulation of endocochlear potential

Research interests

  • Purinergic receptors
  • Cochlear implants
  • Nanoparticles
  • Electrophysiology
  • Auditory neuroscience
  • Pharmacology

Selected publications and creative works (Research Outputs)

  • Chang, H., Telang, R. S., Sreebhavan, S., Tingle, M., Thorne, P. R., & Vlajkovic, S. M. (2017). Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration. BioMed research international, 201710.1155/2017/8091462
    URL: http://hdl.handle.net/2292/33394
    Other University of Auckland co-authors: Malcolm Tingle, Srdjan Vlajkovic, Peter Thorne, Sree Sreebhavan
  • Karunasinghe, R. N., Grey, A. C., Telang, R., Vlajkovic, S. M., & Lipski, J. (2017). Differential spread of anoxic depolarization contributes to the pattern of neuronal injury after oxygen and glucose deprivation (OGD) in the Substantia Nigra in rat brain slices. Neuroscience, 340, 359-372. 10.1016/j.neuroscience.2016.10.067
    URL: http://hdl.handle.net/2292/32713
    Other University of Auckland co-authors: Janusz Lipski, Gus Grey, Srdjan Vlajkovic, Rashika Karunasinghe
  • Telang, R., Vlajkovic, S., Bird, P., Wise, A., Caruso, F., & Thorne, P. (8/9/2016). Use of a nanoengineered drug carrier for intracochlear delivery of otoprotective substances in a cochlear implant animal model. Poster presented at Frontiers 2016 - The Art, Science and Future of Otorhinolaryngology, Gold Coast, Australia.
    Other University of Auckland co-authors: Srdjan Vlajkovic, Peter Thorne
  • Floc'h JL, Tan, W., Telang, R. S., Vlajkovic, S. M., Nuttall, A., Rooney, W. D., ... Thorne, P. R. (2014). Markers of cochlear inflammation using MRI. J Magn Reson Imaging, 39 (1), 150-161. 10.1002/jmri.24144
    URL: http://hdl.handle.net/2292/21401
    Other University of Auckland co-authors: Srdjan Vlajkovic, Peter Thorne, Beau Pontre
  • Vlajkovic, S. M., Chang, H., Paek, S. Y., Chi, H. H.-T., Sreebhavan, S., Telang, R. S., ... Thorne, P. R. (2014). Adenosine amine congener as a cochlear rescue agent. BioMed research international, 2014
    URL: http://hdl.handle.net/2292/24827
    Other University of Auckland co-authors: Malcolm Tingle, Srdjan Vlajkovic, Peter Thorne
  • Telang, R. S., Vlajkovic, S. M., & Thorne, P. R. (24/8/2013). Influence of sound stress on cochlear function and endolymph electrochemistry in aging C57BL/6 mice. Poster presented at 31st Australasian Winter Conference on Brain Research, Queenstown, New Zealand. Proceedings of 31st International Australasian Winter Conference on Brain Research.
    Other University of Auckland co-authors: Srdjan Vlajkovic, Peter Thorne
  • Housley, G. D., Morton-Jones, R., Vlajkovic, S. M., Telang, R. S., Paramananthasivam, V., Tadros, S. F., ... Sivakumaran, Y. (2013). ATP-gated ion channels mediate adaptation to elevated sound levels. Proceedings of the National Academy of Sciences of the United States of America, 110 (18), 7494-7499. 10.1073/pnas.1222295110
    Other University of Auckland co-authors: Peter Thorne, Srdjan Vlajkovic
  • Sharma, D. K., Telang, R. S., & Varshneya, C. (2013). Free radicals spare KCL but reversibly impair NE mediated vascular contractility in goat isolated pulmonary artery in vitro. Journal of Cell and Tissue Research, 13 (1), 3495-3498.