Dr Ravi Telang

BVSc & AH, MVSc, PhD

Research | Current

Hearing loss in young adults and old people is emerging as one of the largest disability groups worldwide. In New Zealand and Australia it affects 1 in 6 people, a prevalence expected to rise to 1 in 4 by 2050. Hearing loss occurs predominately through injury or disease of the inner ear. Unfortunately, hair cells and neurons do not regenerate following injury. In the absence of treatments for the injury the only option for many is a hearing aid or cochlear implant in profundly deaf subjects.

Cochlear implants success is marred by the inflammatory response in inner ear due to surgical trauma. My lab is working on improving the outcome of cochlear implants through the novel use of MS-PGA nanoparticles as drug carriers. We are investigating the potential use of adenosine receptor agonists and neurotrophins to reduce hair cell and neural injury following implantation in animals with residual hearing.

Our lab has done some interesting research on following aspects of auditory neuroscience in past:

  • Age related changes in cochlear purinergic signalling, and the modulatory role of ATP
  • Role of purinergic P2X2 receptors in noise stress handling mechanisms of cochlea
  • Ionic homeostasis in inner ear, as influenced by ageing and noise trauma
  • Adaptive regulation of endocochlear potential

Research interests

  • Purinergic receptors
  • Cochlear implants
  • Nanoparticles
  • Electrophysiology
  • Auditory neuroscience
  • Pharmacology

Selected publications and creative works (Research Outputs)