Sir Richard Lewis Maxwell Faull
KNZM BMedSc MBChB PhD DSc FRSNZ
Research | Current
- Human neurodegenerative diseases
- Alzheimer's disease
- Huntington's disease
- Parkinson's disease
We have a broadly-based, multidisciplinary HRC Research Programme on "Neurodegeneration in the Human Brain - Mechanisms and Therapeutic Targets" in collaboration with Dr Henry Waldvogel and Dr Maurice Curtis (Department of Anatomy with Radiology), Professor Mike Dragunow and Dr Michelle Glass in the Department of Pharmacology, and Dr Lynette Tippett (Department of Psychology) , which uses the human tissue stored in our Human Brain Bank and the molecular, cellular biological and imaging resources in the Centre for Brain Research. Research in the group is focused on the following major project areas:
- Molecular biological and anatomical studies on the chemical changes in the following major neurodegenerative diseases of the human brain – Huntington’s disease, Alzheimer’s disease, schizophrenia, Parkinson’s disease, epilepsy and Motor Neuron disease.
- Correlation of the clinical profile with the chemical anatomical pathology and genotype in Huntington’s disease, in order to determine whether variations in clinical symptomatology are reflected by variations in the chemical pathology and HD gene.
- The establishment of a transgenic sheep model of Huntington's disease in collaboration with Dr Russell Snell (School of Biological Sciences), Dr Simon Bawden (South Australian Research Development Institute), and Dr Marcy Macdonald and Professor Jim Gusella (Harvard University). This will be the first large animal model of a human brain disease in the world and will provide for studies on the pathogenesis and molecular mechanisms of Huntington's disease and, most importantly, will provide an animal model (whose brain is very similar to the human brain) for the development of novel therapeutic strategies for treating this tragic inherited human brain disease. This project has receceived major funding from The Freemasons of New Zealand.
- Molecular mechanisms and patterns of nerve cell death and repair in these neurodegenerative diseases focusing on the role of transcription factors and growth factors, and using in vitro cell culture models, and transgenic animal models.
- Investigations on the potential of various novel methods to treat neurodegenerative diseases including gene therapy techniques (decoy DNA, antisense DNA, peptide nucleic acids), and neurotrophins to prevent neuronal death in neurodegenerative diseases.
- In collaboration with Dr Bronwen Connor and Professor Mike Dragunow in Pharmacology, and Dr Maurice Curtis (University of Goteborg, Sweden) we are also studying neurogenesis in the human brain. The specific areas of interest are: (i) whether stem cells in the adult human brain and spinal cord have the ability to proliferate and form new neurons in response to brain injury and disease (Huntington's disease, Parkinson's Disease, Epilepsy, Alzheimer's disease, Motor Neuron Disease, Stroke); (ii) the pathways of neurogenesis in the human brain; (iii) the mechanisms involved in the induction of neurogenesis in the injured or diseased adult brain; and (iii) do stem cells have the potential to ‘repair’ the injured or diseased adult brain and spinal cord.
Selected publications and creative works (Research Outputs)
- Swanson, M. E. V., Murray, H. C., Ryan, B., Faull, R. L. M., Dragunow, M., & Curtis, M. A. (2020). Quantitative immunohistochemical analysis of myeloid cell marker expression in human cortex captures microglia heterogeneity with anatomical context. Scientific Reports, 10 (1).10.1038/s41598-020-68086-z
Other University of Auckland co-authors: Molly Swanson, Helen Murray, Maurice Curtis
- Murray, H. C., Dieriks, B. V., Swanson, M. E. V., Anekal, P. V., Turner, C., Faull, R. L. M., ... Curtis, M. A. (2020). The unfolded protein response is activated in the olfactory system in Alzheimer's disease. Acta Neuropathologica Communications, 8 (1)10.1186/s40478-020-00986-7
Other University of Auckland co-authors: Victor Dieriks, Helen Murray, Molly Swanson, Maurice Curtis
- Choi, P. J., Cooper, E., Schweder, P., Mee, E., Turner, C., Faull, R., ... Jose, J. (2020). PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines. Bioorganic & Medicinal Chemistry Letters, 30 (14)10.1016/j.bmcl.2020.127252
Other University of Auckland co-authors: Peter Choi, Bill Denny, Michael Dragunow, Thomas Park, Jiney Jose
- Wu, J. J., Cai, A., Greenslade, J. E., Higgins, N. R., Fan, C., Le, N. T. T., ... Dieriks, B. V. (2020). ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function. Proceedings of the National Academy of Sciences of the United States of America, 117 (26), 15230-15241. 10.1073/pnas.1917371117
Other University of Auckland co-authors: Emma Scotter, Victor Dieriks, Maurice Curtis
- Yeung, J. H. Y., Calvo-Flores Guzmán B, Palpagama, T. H., Ethiraj, J., Zhai, Y., Tate, W. P., ... Kwakowsky, A. (2020). Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus. Journal of neurochemistry10.1111/jnc.15099
Other University of Auckland co-authors: Henry Waldvogel, Andrea Kwakowsky
- Huang, T.-T., Smith, R., Bacos, K., Song, D.-Y., Faull, R. M., Waldvogel, H. J., & Li, J.-Y. (2020). No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease. Acta neuropathologica communications, 8 (1)10.1186/s40478-020-00949-y
Other University of Auckland co-authors: Henry Waldvogel
- Xu, J., Patassini, S., Begley, P., Church, S., Waldvogel, H. J., Faull, R. L. M., ... Cooper, G. J. S. (2020). Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease. Biochemical and biophysical research communications, 527 (3), 676-681. 10.1016/j.bbrc.2020.05.015
Other University of Auckland co-authors: Henry Waldvogel, Garth Cooper
- Govindpani, K., Vinnakota, C., Waldvogel, H. J., Faull, R. L., & Kwakowsky, A. (2020). Vascular dysfunction in Alzheimer's disease: a biomarker of disease progression and a potential therapeutic target. NEURAL REGENERATION RESEARCH, 15 (6), 1030-1032. 10.4103/1673-5374.270306
Other University of Auckland co-authors: Henry Waldvogel, Karan Govindpani, Andrea Kwakowsky