Dr Stephen Jamieson

BSc, MSc, PhD

Biography

I graduated from my PhD in cancer pharmacology in 2006 at The University of Auckland under the supervision of Prof. Mark McKeage. I then worked as a postdoctoral research scientist in the drug discovery laboratories at Cancer Research Technology Ltd in London, UK for 2 years, before returning to the University of Auckland and joining the Auckland Cancer Society Research Centre in late 2008. In 2016, I was appointed to a dual position in the ACSRC and Department of Pharmacology and Clinical Pharmacology. I am an associate investigator of the Maurice Wilkins Centre for Molecular Biodiscovery

Research | Current

My research is focussed on the preclinical development of novel anticancer drugs, utilising cell biology and pharmacology models of human cancer to progress novel anticancer drugs into clinical trials. My research has directly contributed to the entry into phase I clinical trials of the PI3-kinase inhibitor, PWT-33597, and the EGFR/HER2 inhibitor, tarloxotinib. Current drug discovery research projects include the development of small molecule inhibitors or prodrugs that selectively target:

  • Tumour hypoxia
  • Colony stimulating factor 1 receptor (CSF-1R)
  • Phosphoinositide 3-kinase
  • Heparanase
  • Perforin

Other research interests include the development of patient-derived tumour xenografts of head and neck cancer and whole genome CRISPR/Cas9 knockout screens for biomarker or target identification. These technologies are being used to

  • Identify novel predictive biomarkers of hypoxia-activated prodrugs in head and neck cancer
  • Evaluate efficacy of anticancer agents in clinically relevant tumour models of head and neck cancer
  • Identify genes that modulate sensitivity to tumour microenvironment stress

 

Research group

Teaching | Current

Course director for MEDSCI 716

Areas of expertise

  • Preclinical drug development
  • In vivo pharmacology
  • Patient derived xenografts
  • CRISPR/Cas9 gene editing
  • Next generation sequencing
  • Drug pharmacokinetics
  • Preclinical tumour models

Selected publications and creative works (Research Outputs)

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level 0, Room 001
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand