Dr Suresh Muthukumaraswamy
Suresh completed his PhD in psychology at the University of Auckland in 2005 after which he joined the newly established Cardiff University Brain Research Imaging Centre as a post-doctoral fellow. In 2014 Suresh received a Rutherford Discovery Fellowship and has returned to Auckland where he works in both the School of Pharmacy (Faculty of Medicine and Health Sciences) and School of Psychology (Faculty of Science).
Research | Current
Suresh’s main research interests are in understanding how therapies alter brain activity and in developing methodologies to measure these changes in both healthy individuals and patient groups. His previous studies have involved a range of compounds including hallucinogens (ketamine, LSD, psilocybin), anaesthetics (propofol, dexmedetomidine), anti-epileptics (vigabatrin, perampanel, tiagabine) and GABA-enhancers (zolpidem, gaboxadol). Suresh’s research has used a wide-range of neuroimaging techniques including magnetoencephalography, electroencephalography, functional magnetic resonance imaging and magnetic resonance spectroscopy.
Examples of current research projects include
1. Simultaneous EEG/fMRI studies of ketamine and midazolam
2. Brain imaging the effects of ketamine in treatment-resistant depression
3. The use of rapid transcranial magnetic stimulation in treatment-resistant depression
4. Menstrual cycle effects on cortical excitation and plasticity
Suresh has an extensive network of scientific and clinical collaborators in both New Zealand and the United Kingdom
Teaching | Current
Pharmacy 410 - Research Dissertation
Psychology 788 - Honours Dissertation
Psychology 305 - Human Neuroscience
Psychology 202 Biopsychology
Yaqub Jonmohamadi (Postdoctoral Fellow)
Rachael Sumner (PhD student)
Anna Forsyth (PhD student)
Rebecca McMillan (PhD student)
Kate Godfrey (PhD Student)
Kelan Li (BSc (hons) student)
Students interested in doing with research with Suresh are welcome to get in touch with him. Students doing research with Suresh will generally be exposed to human psychopharmacology research using EEG and/or fMRI. A background in neuroscience is preferable and a willingness to learn computational techniques (usually in MATLAB) essential.
Rutherford Discovery Fellowship (2014). Royal Society of New Zealand.
Postgraduate Advisor. School of Pharmacy.
Areas of expertise
Editorial Board: NeuroImage
Editorial Board: AIMS Neuroscience
Research Advisory Committee : Centre for Brain Research
Selected publications and creative works (Research Outputs)
- Muthukumaraswamy, S. D., Routley, B., Droog, W., Singh, K. D., & Hamandi, K. (2016). The effects of AMPA blockade on the spectral profile of human early visual cortex recordings studied with non-invasive MEG. Cortex, 81, 266-275. 10.1016/j.cortex.2016.03.004
- Tagliazucchi, E., Roseman, L., Kaelen, M., Orban, C., Muthukumaraswamy, S. D., Murphy, K., ... Crossley, N. (2016). Increased global functional connectivity correlates with LSD-induced ego dissolution. Current Biology, 26 (8), 1043-1050. 10.1016/j.cub.2016.02.010
- Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., ... Orban, C. (2016). Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences, 113 (17), 4853-4858. 10.1073/pnas.1518377113
- Muthukumaraswamy, S. D., Shaw, A. D., Jackson, L. E., Hall, J., Moran, R., & Saxena, N. (2015). Evidence that subanesthetic doses of ketamine cause sustained disruptions of NMDA and AMPA-mediated frontoparietal connectivity in humans. The Journal of Neuroscience, 35 (33), 11694-11706. 10.1523/JNEUROSCI.0903-15.2015
- Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R. J., Brookes, M. J., Williams, T. M., Errtizoe, D., ... Singh, K. D. (2013). Broadband cortical desynchronization underlies the human psychedelic state. The Journal of Neuroscience, 33 (38), 15171-15183. 10.1523/JNEUROSCI.2063-13.2013
- Edden, R. A. E., Muthukumaraswamy, S. D., Freeman, T. C. A., & Singh, K. D. (2009). Orientation discrimination performance is predicted by GABA concentration and gamma oscillation frequency in human primary visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29 (50), 15721-15726. 10.1523/jneurosci.4426-09.2009
- Muthukumaraswamy, S. D., & Singh, K. D. (2009). Functional decoupling of BOLD and gamma-band amplitudes in human primary visual cortex. Human brain mapping, 30 (7), 2000-2007. 10.1002/hbm.20644
- Muthukumaraswamy, S. D., Edden, R. A. E., Jones, D. K., Swettenham, J. B., & Singh, K. D. (2009). Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans. Proceedings of the National Academy of Sciences of the United States of America, 106 (20), 8356-8361. 10.1073/pnas.0900728106