Dr Simon Joseph OCarroll

BSc, MSc (First Class Honours), PhD

Biography

Research interests

Research | Current

Simon is Director of the Spinal Cord Injury Research Facility, located in the Centre for Brain Research. Simon's current research interests involve understanding the mechanisms of damage involved in spinal cord injury and developing therapeutic interventions that modulate neuroinflammation and scar formation following injury. He is also interested in the role of the blood brain barrier in central nervous system disease development and uses in vivo and real time cell culture methods to study changes that occur at the blood brain barrier following neuroinflammatory and traumatic insult.

Postgraduate supervision

Jarred Griffin, PhD - supervisor

Tania Fowke, PhD - co-supervisor

Rebecca Johnson, PhD - co-supervisor

Akshata Anchan, PhD - co-supervisor

Andrea Gu, MSc, - supervisor

Connor Clemmett, Honours - supervisor

 

Areas of expertise

Spinal cord injury

Neuroinflammation

Blood brain barrier

Real-time cell culture analyis

Selected publications and creative works (Research Outputs)

  • Mao, Y., Tonkin, R. S., Nguyen, T., O'Carroll SJ, Nicholson, L. F. B., Green, C. R., ... Gorrie, C. A. (2017). Systemic Administration of Connexin43 Mimetic Peptide Improves Functional Recovery after Traumatic Spinal Cord Injury in Adult Rats. Journal of neurotrauma, 34 (3), 707-719. 10.1089/neu.2016.4625
    Other University of Auckland co-authors: Colin Green
  • Griffin, J. M., Kho, D., Graham, E. S., Nicholson, L. F. B., & O'Carroll SJ (2016). Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier. PloS one, 11 (6)10.1371/journal.pone.0157483
    URL: http://hdl.handle.net/2292/31398
    Other University of Auckland co-authors: Jarred Griffin, Scott Graham, Dan Kho
  • O'Carroll SJ, Kho, D. T., Wiltshire, R., Nelson, V., Rotimi, O., Johnson, R., ... Graham, E. S. (2015). Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. Journal of neuroinflammation, 1210.1186/s12974-015-0346-0
    URL: http://hdl.handle.net/2292/30036
    Other University of Auckland co-authors: Scott Graham, Catherine Angel, Lola Mugisho, Dan Kho
  • O'Carroll SJ, Gorrie, C. A., Velamoor, S., Green, C. R., & Nicholson, L. F. B. (2013). Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury. Neuroscience Research, 75 (3), 256-267. 10.1016/j.neures.2013.01.004
    Other University of Auckland co-authors: Colin Green
  • O'Carroll SJ, Becker, D. L., Davidson, J. O., Gunn, A. J., Nicholson, L. F. B., & Green, C. R. (2013). The use of connexin-based therapeutic approaches to target inflammatory diseases. Methods in Molecular Biology, 1037, 519-546. 10.1007/978-1-62703-505-7_31
    Other University of Auckland co-authors: Alistair Gunn
  • O'Carroll SJ, Alkadhi, M., Nicholson, L. F. B., & Green, C. R. (2008). Connexin43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury. CELL COMMUNICATION AND ADHESION, 15 (1-2), 27-42. 10.1080/15419060802014164
    URL: http://hdl.handle.net/2292/9230
    Other University of Auckland co-authors: Colin Green

Contact details

Primary location

M&HS BUILDING 502 - Bldg 502
Level 5, Room 501
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand