Associate Professor Srdjan M Vlajkovic

MBChB, PhD

Biography

EDUCATIONAL QUALIFICATIONS:

PhD, Neuroscience, University of Belgrade

MSc, Immunology, University of Belgrade

MBChB, General medicine and surgery, University of Belgrade

 

PREVIOUS APPOINTMENTS:

University of Auckland – Senior Lecturer

University of Auckland – Senior Research Fellow

Harvard University – visiting scientist

University of Auckland – Research Fellow

Immunology Research Centre, University of Belgrade – Research Fellow

Emory University (Atlanta) – Postdoctoral Fellow

 

Research | Current

Srdjan's principal research interest is in the field of Auditory Neuroscience. He investigates cellular and molecular basis of cochlear homeostasis, and the mechanisms of sensorineural hearing loss. His primary focus is on the role of oxidative stress and inflammation in the development of noise-induced and age-related hearing loss. Understanding how purines (ATP and adenosine) are involved in cochlear physiology and the development of cochlear injury has revealed novel mechanisms of adaptation to noise and provided a novel therapeutic target for sensorineural hearing loss. 

Research collaborations

  • Principle collaboration with Professor Peter Thorne 
  • International collaborators: Professors Gary Housley (University of New South Wales, Sydney), Detlev Boison (Portland, USA), Simon Robson  (Harvard University) 

Research interests

  • Neuroscience
  • Hearing
  • Deafness
  • Auditory neurobiology
  • Neuroprotection
  • Molecular neuroscience
  • Purinergic signalling

Postgraduate supervision

Current PhD students:

Principal supervisor:

1.     Hao Chang “Adenosine Amine Congener as a cochlear rescue agent after acoustic trauma”

2.     Shelly Lin “The role of extracellular nucleotides in the maintenance of sensory hair cells in the cochlea”

3.     Winston Tan “Cochlear inflammation: mechanisms and therapies”

 

Co-supervisor:

4.     Michael Bergin “A model of the surgical forces on the middle ear and associated effects on the inner ear” 

5.     Rashika Karunasinghe “Hypoxic spreading depression (HSD) in the Substantia Nigra”

6.     Nishani Dayaratne “Role of oxidative stress and mitochondrial function in cochlear tissue

Distinctions/Honours

Editorial Board member:

Research Journal of Aging

Advances in Medicine

Dataset Papers in Medicine

World Journal of Otorhinolaryngology

 

 

Responsibilities

  • Associate Professor
  • Principal Investigator, Auckland Auditory Neuroscience Group

Areas of expertise

Auditory Neuroscience, purinergic signalling

Committees/Professional groups/Services

2011-present, BSc Honours Skills Programme Co-ordinator

2012-2013, Human Participants Ethics Committee, Member

2005-2011, Animal Ethics Committee (UoA), Member

Selected publications and creative works (Research Outputs)

  • Floc'h JL, Tan, W., Telang, R. S., Vlajkovic, S. M., Nuttall, A., Rooney, W. D., ... Thorne, P. R. (2014). Markers of cochlear inflammation using MRI. Journal of Magnetic Resonance Imaging, 39 (1), 150-161. 10.1002/jmri.24144
    URL: http://hdl.handle.net/2292/21401
    Other University of Auckland co-authors: Ravi Telang, Peter Thorne, Beau Pontre
  • Vlajkovic, S. M., Lin, S. C. Y., Wong, A. C. Y., Wackrow, B., & Thorne, P. R. (2013). Noise-induced changes in expression levels of NADPH oxidases in the cochlea. Hearing Research, 304, 145-152. 10.1016/j.heares.2013.07.012
    Other University of Auckland co-authors: Peter Thorne
  • Tan, W. J. T., Thorne, P. R., & Vlajkovic, S. M. (2013). Noise-induced cochlear inflammation. World Journal of Otorhinolaryngology, 3 (3), 89-99. 10.5319/wjo.v3.i3.89
    Other University of Auckland co-authors: Peter Thorne
  • Housley, G. D., Morton-Jones, R., Vlajkovic, S. M., Telang, R. S., Paramananthasivam, V., Tadros, S. F., ... Sivakumaran, Y. (2013). ATP-gated ion channels mediate adaptation to elevated sound levels. Proceedings of the National Academy of Sciences of the United States of America, 110 (18), 7494-7499. 10.1073/pnas.1222295110
    Other University of Auckland co-authors: Ravi Telang, Peter Thorne
  • Yan, D., Zhu, Y., Walsh, T., Xie, D., Yuan, H., Sirmaci, A., ... Du, L. (2013). Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise. Proceedings of the National Academy of Sciences of the United States of America, 110 (6), 2228-2233. 10.1073/pnas.1222285110
    Other University of Auckland co-authors: Peter Thorne
  • Gunewardene, N., Guo, C. X., Wong, A. C. Y., Thorne, P. R., & Vlajkovic, S. M. (2013). Adenosine Amine Congener ameliorates cisplatin-induced hearing loss. World Journal of Otorhinolaryngology, 3 (3), 100-107. 10.5319/wjo.v3.i3.100
    URL: http://hdl.handle.net/2292/30320
    Other University of Auckland co-authors: Peter Thorne
  • Vlajkovic, S. M., Guo, C. X., Telang, R., Wong, A. C. Y., Paramananthasivam, V., Boison, D., ... Thorne, P. R. (2011). Adenosine kinase inhibition in the cochlea delays the progression of age-related hearing loss. Experimental Gerontology, 46 (11), 905-914. 10.1016/j.exger.2011.08.001
    URL: http://hdl.handle.net/2292/15628

Identifiers

Contact details

Primary location

M&HS BUILDING 502 - Bldg 502
Level 4, Room 401D
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links