Dr Samantha Jane Holdsworth

BSc (Hons) Physics Canterbury, MSc Medical Physics QUT Australia, PhD Radiology UQ Australia.

Biography

Samantha has a background in medical physics and imaging. Her research focus is on novel, fast, and effective ways of imaging the brain using Magnetic Resonance Imaging (MRI). Samantha’s improved imaging and image-processing methodologies have led to better diagnoses in clinical applications such as stroke and neurodegenerative disease. Some of these methods are currently being used as fast MRI alternatives at Stanford University’s Hospital where she worked for 11 years. Samantha is a pioneer of high resolution diffusion-weighted imaging (DWI, DTI), fast susceptibility-weighted imaging (SWI), and amplified MRI (aMRI) – a novel method of visualizing pulsatile brain motion. Further research into aMRI may allow us to understand the effect of obstructive disorders of the brain and also provide a means of measuring the brain’s biomechanical properties that would lead to several clinical applications. Her current research interests are in the application of new imaging methods to understanding mild Traumatic Brain Injury (mTBI). 

Areas of expertise

Developing new fast/high resolution Magnetic Resonance Imaging (MRI) and image processing methods

New MRI contrast mechanisms

Simultaneous whole-body PET/MRI

Translating research MRI & image reconstruction methods to the clinics. 

Selected publications and creative works (Research Outputs)

  • Muehe, A., Theruvath, A., Lai, L., Aghighi, M., Quon, A., Holdsworth, S., ... Advani, R. (2018). How to provide gadolinium-free PET/MR cancer staging of children and young adults in less than 1 h: The Stanford approach. Molecular Imaging and Biology10.1007/s11307-017-1105-7
  • Holdsworth, S., Rahimi, M. S., Ni, W., Zaharchuk, G., & Moseley, M. (2016). Amplified magnetic resonance imaging (aMRI). Magnetic Resonance in Medicine, 75 (6), 2245-2254. 10.1002/mrm.26142
  • Fan, A., Jahanian, H., Holdsworth, S., & Zaharchuk, G. (2016). Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: A systematic review. Journal of Cerebral Blood Flow and Metabolism, 36 (5), 842-861. 10.1177/0271678X16636393
  • Vos, S., Aksoy, M., Han, Z., Holdsworth, S., Maclaren, J., Viergever, M., ... Bammer, R. (2016). Trade-off between angular and spatial resolutions in in vivo fiber tractography. NeuroImage, 129, 117-132. 10.1016/j.neuroimage.2016.01.011
  • Holdsworth, S. J., Yeom, K. W., Moseley, M. E., & Skare, S. (2015). Fast susceptibility-weighted imaging with three-dimensional short-axis propeller (SAP)-echo-planar imaging. Journal of Magnetic Resonance Imaging, 41 (5), 1447-1453. 10.1002/jmri.24675
  • Iv, M., Telischak, N., Feng, D., Holdsworth, S., Yeom, K., & Daldrup-Link, H. (2015). Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors. Nanomedicine, 10 (6), 993-1018. 10.2217/nnm.14.203
  • Van, A., Aksoy, M., Holdsworth, S., Kopeinigg, D., Vos, S., & Bammer, R. (2015). Slab profile encoding (PEN) for minimizing slab boundary artifact in three-dimensional diffusion-weighted multislab acquisition. Magnetic Resonance in Medicine, 73 (2), 605-613. 10.1002/mrm.25169
  • Holdsworth, S. J., Yeom, K. W., Antonucci, M. U., Andre, J. B., Rosenberg, J., Aksoy, M., ... Moseley, M. E. (2014). Diffusion-weighted imaging with dual-echo echo-planar imaging for better sensitivity to acute stroke. American Journal of Neuroradiology, 35 (7), 1293-1302. 10.3174/ajnr.A3921