Dr Shu Meng
BE Northeastern University
Shu Meng received a Bachelor of Engineering in Biomedical Engineering from the Northeastern University (China) in 2011. She was awarded a doctoral scholarship by the China Scholarship Council (CSC) after graduation.
Since the beginning of 2012, Shu has been a doctoral student in the cardiac electrophysiology research group.
Research | Current
Accurate endocardial activation representation of atria by intracavity inverse mapping
Atrial fibrillation (AF) is the most common heart rhythm disturbance, and radiofrequency catheter ablation has been widely used to treat AF with certain success. However, despite “optimally” combined ablation approaches, the success rate for persistent AF (PeAF) remains low. A major hurdle is that the complex functional and anatomic substrates of PeAF and lacking of effective mapping tools to construct representative electrical activations during AF. To address this problem, our group aims to develop a novel, noncontact, “open”, multi-electrode mapping system to reconstruct panoramic electrical activation in atrial chambers simultaneously by intracavity inverse mapping.
We have developed a novel numerical approach to accurately estimate Neumann boundary conditions on the catheter surface accurately by employing forward solution and numerical derivatives. Then we have integrated the estimated Neumann boundary conditions into a finite element inverse problem package and employed this as a powerful tool to investigate the feasibility and sensitivity of the proposed mapping study.
Our results indicate that the potential-based, intracavity inverse mapping is capable of accurately reconstructing electrical activation patters on the endocardial surface. Furthermore, we have demonstrated that the optimized geometry meshes, diameter and flexibility of basket catheters are important factors for accurate inverse mapping.
Selected publications and creative works (Research Outputs)
- Meng, S. (2017). A Systematic Investigation of Intracardiac Inverse Mapping The University of Auckland. ResearchSpace@Auckland.
- Zhao, J., Krueger, M. W., Seemann, G., Meng, S., Zhang, H., Dössel O, ... Smaill, B. H. (2012). Myofiber orientation and electrical activation in human and sheep atrial models. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 6365-6368.
Other University of Auckland co-authors: Ian LeGrice, Jichao Zhao
- Meng, S., Zhao, J. C., Lever, N. A., LeGrice, I. J., & Smaill, B. H. (2012). Accurate endocardial activation representation of atria by noncontact mapping. Paper presented at 39th Conference on Computing in Cardiology, Krakow, POLAND. 9 September - 12 September 2012. 2012 COMPUTING IN CARDIOLOGY (CINC),.
Other University of Auckland co-authors: Jichao Zhao, Ian LeGrice, Nigel Lever