Dr Troy Leslie Merry
Troy completed a Bachelor of Physical Education with honor at the University of Otago before undertaking a PhD in exercise metabolism at the University of Melbourne. During two post-doctoral studies at Monash University, Australia, and the ETH (Swiss Federal Institute of Technology) Zurich, Switzerland Troy investigated the role of reactive oxygen species (ROS) in regulating metabolism and glucose homeostasis before returning to New Zealand in 2016.
Research | Current
Exercise and Molecular Metabolism
Our laboratory focuses on understand the cellular signalling mechanisms and metabolic parameters that regulate the develop obesity, type 2 diabetes and fatty liver disease, in an effort to develop novel treatments for these metabolic diseases. We have a particular interest in investigating the pathways through which exercise improves our metabolic health and targeting these pathways to prevent metabolic dysfunction. Our research uses a combination of experimental approaches including genetically modified mouse models, cell culture and involve human clinical type trials in combination with molecular techniques.
Teaching | Current
Selected publications and creative works (Research Outputs)
- Merry, T. L., Chan, A., Woodhead, J. S. T., Reynolds, J. C., Kumagai, H., Kim, S., & Lee, C. (2020). Mitochondrial-derived peptides in energy metabolism. American Journal of Physiology - Endocrinology and Metabolism Related URL.
- Pham, T., MacRae, C. L., Broome, S. C., D'souza RF, Narang, R., Wang, H. W., ... Merry, T. L. (2020). MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. European journal of applied physiology, 120 (7), 1657-1669. 10.1007/s00421-020-04396-4
Other University of Auckland co-authors: Toan Pham, Caitlin Macrae
- Rettedal, E. A., Cree, J. M. E., Adams, S. E., MacRae, C., Skidmore, P. M. L., Cameron-Smith, D., ... Merry, T. L. (2020). Short-term high-intensity interval training exercise does not affect gut bacterial community diversity or composition of lean and overweight men. Experimental physiology10.1113/ep088744
Other University of Auckland co-authors: Cherie Blenkiron, David Cameron-Smith, Nick Gant
- Woodhead, J. S. T., D'Souza RF, Hedges, C. P., Wan, J., Berridge, M. V., Cameron-Smith, D., ... Merry, T. L. (2020). High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. Journal of applied physiology (Bethesda, Md. : 1985), 128 (5), 1346-1354. 10.1152/japplphysiol.00032.2020
Other University of Auckland co-authors: Chris Hedges, David Cameron-Smith, Randall D'Souza
- Merry, T. L., Hedges, C. P., Masson, S. W., Laube, B., Pöhlmann D, Wueest, S., ... Konrad, D. (2020). Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease. Nature communications, 11 (1)10.1038/s41467-020-15623-z
Other University of Auckland co-authors: Chris Hedges
- D'Souza RF, Woodhead, J. S. T., Hedges, C. P., Zeng, N., Wan, J., Kumagai, H., ... Mitchell, C. J. (2020). Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging, 12 (6), 5244-5258. 10.18632/aging.102944
Other University of Auckland co-authors: David Cameron-Smith, Randall D'Souza, Chris Hedges
- Merry, T. L., Brooks, A. E. S., Masson, S. W., Adams, S. E., Jaiswal, J. K., Jamieson, S. M. F., & Shepherd, P. R. (2020). The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice. International journal of obesity (2005), 44 (1), 245-253. 10.1038/s41366-019-0355-7
Other University of Auckland co-authors: Anna Brooks, Jagdish Jaiswal, Stephen Jamieson
- Merry, T. L., MacRae, C., Pham, T., Hedges, C. P., & Ristow, M. (2019). Deficiency in the ROS-sensing Nuclear Factor Erythroid 2-like 2 (Nrf2) causes altered glucose and lipid homeostasis following exercise training. American Journal of Physiology - Cell Physiology10.1152/ajpcell.00426.2019
Other University of Auckland co-authors: Caitlin Macrae, Chris Hedges, Toan Pham