Dr Troy Leslie Merry
Troy completed a Bachelor of Physical Education with honor at the University of Otago before undertaking a PhD in exercise metabolism at the University of Melbourne. During two post-doctoral studies at Monash University, Australia, and the ETH (Swiss Federal Institute of Technology) Zurich, Switzerland Troy investigated the role of reactive oxygen species (ROS) in regulating metabolism and glucose homeostasis before returning to New Zealand in 2016.
Research | Current
Exercise and Molecular Metabolism
Our laboratory focuses on understand the cellular signalling mechanisms and metabolic parameters that regulate the develop obesity, type 2 diabetes and fatty liver disease, in an effort to develop novel treatments for these metabolic diseases. We have a particular interest in investigating the pathways through which exercise improves our metabolic health and targeting these pathways to prevent metabolic dysfunction. Our research uses a combination of experimental approaches including genetically modified mouse models, cell culture and involve human clinical type trials in combination with molecular techniques.
Teaching | Current
Selected publications and creative works (Research Outputs)
- Merry, T. L., Kuhlow, D., Laube, B., Pöhlmann D, Pfeiffer, A. F. H., Kahn, C. R., ... Zarse, K. (2017). Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan. Aging Cell, 16 (4), 761-772. 10.1111/acel.12610
- Merry, T. L., Tran, M., Dodd, G. T., Mangiafico, S. P., Wiede, F., Kaur, S., ... Tiganis, T. (2016). Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice. Diabetologia, 59 (12), 2632-2644. 10.1007/s00125-016-4084-3
- Merry, T. L., & Ristow, M. (2016). Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice. The Journal of Physiology, 594 (18), 5195-5207. 10.1113/JP271957
- Merry, T. L., & Ristow, M. (2016). Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?. The Journal of Physiology, 594 (18), 5135-5147. 10.1113/JP270654
- Merry, T. L., & Ristow, M. (2016). Mitohormesis in exercise training. Free Radical Biology and Medicine, 98, 123-130. 10.1016/j.freeradbiomed.2015.11.032
- Galimov, A., Merry, T. L., Luca, E., Rushing, E. J., Mizbani, A., Turcekova, K., ... Krützfeldt J (2016). MicroRNA-29a in Adult Muscle Stem Cells Controls Skeletal Muscle Regeneration During Injury and Exercise Downstream of Fibroblast Growth Factor-2. STEM CELLS, 34 (3), 768-780. 10.1002/stem.2281
- Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., ... Kahn, B. B. (2015). Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat. Cell, 160 (1-2), 88-104. 10.1016/j.cell.2014.12.022
- Gurzov, E. N., Tran, M., Fernandez-Rojo, M. A., Merry, T. L., Zhang, X., Xu, Y., ... Andrikopoulos, S. (2014). Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2. Cell Metabolism, 20 (1), 85-102. 10.1016/j.cmet.2014.05.011