Mr Utpal Prodhan

MSc in Applied Nutrition and Food Technology

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Doctoral Candidate - Doctor of Philosophy

Research | Current

Elevated Branched-chain amino acids (BCAA) has been shown to correlate with an increased risk of insulin resistance (IR) and T2DM. Metabolic profiling demonstrates that BCAAs have emerged as a potential biomarker of a metabolic dysregulated status rather than an initiating event in the causal chain, as their concentrations appear to be elevated many years prior to the onset of T2DM. However, whether circulatory concentrations of AA are impacted by quality and quantity of dietary protein, protein digestion rate, disease states and ageing related phenomenon remains an area of controversy. Thus in the synchronization of the exploration, this thesis is hypothesized to unveil the novel interplay between manipulation of dietary protein intake and related twists in protein digestion to their reflective circulatory AA and metabolic health. Primarily, decisive acute and chronic response of circulatory AA due to diverse dietary modification will be investigated. Subsequently, the changes in circulatory AA including BCAA will be investigated during pre-disease states as a means of dietary weight loss of overweight adults. As an outcome, if dietary alterations or improvement in metabolic health influence fasting BCAA levels, then this tactic could be realistic to apply in future studies to explore the mechanisms associating fasting levels of BCAA to altered metabolic state or as unique methods for improving insulin sensitivity. Apart from the impact of protein qualities and quantities, how digestion related multi-phenomena affect absorption of its constituent AA into the circulation will be investigated exclusively. Profiling of BCAA along with other AA in ageing and subjects with digestive intolerance is opted to clarify the grounds of the apparent improvement in metabolic health. 

Selected publications and creative works (Research Outputs)

  • Zeng, N., Prodhan, U., D'Souza RF, Ramzan, F., Mitchell, S. M., Sharma, P., ... Wagner, K.-H. (2019). Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men. The journal of nutrition, health & aging, 23 (4), 354-363. 10.1007/s12603-019-1171-4
    Other University of Auckland co-authors: Farha Ramzan, David Cameron-Smith, Amber Milan, Randall D'Souza
  • Prodhan, U. K., Milan, A. M., Thorstensen, E. B., Barnett, M. P. G., Stewart, R. A. H., Benatar, J. R., & Cameron-Smith, D. (2018). Altered Dairy Protein Intake Does Not Alter Circulatory Branched Chain Amino Acids in Healthy Adults: A Randomized Controlled Trial. Nutrients, 10 (10).10.3390/nu10101510
    Other University of Auckland co-authors: Amber Milan, Eric Thorstensen, David Cameron-Smith, Ralph Stewart
  • Milan, A. M., Hodgkinson, A. J., Mitchell, S. M., Prodhan, U. K., Prosser, C. G., Carpenter, E. A., ... Cameron-Smith, D. (2018). Digestive Responses to Fortified Cow or Goat Dairy Drinks: A Randomised Controlled Trial. Nutrients, 10 (10).10.3390/nu10101492
    Other University of Auckland co-authors: Amber Milan, David Cameron-Smith

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level B, Room B01
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand