Dr Victor Birger Dieriks

B. Eng, MSc, MBE, MCE, PhD

Biography

  • Dieriks, B. V., Dean, J. M., Aronica, E., Waldvogel, H. J., Faull, R. L. M., & Curtis, M. A. (2018). Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone. Developmental neuroscience. doi:10.1159/000487633
  • Murray, H. C., Swanson, M. E. V., Dieriks, B. V., Turner, C., Faull, R. L. M., & Curtis, M. A. (2018). Neurochemical Characterization of PSA-NCAM+ Cells in the Human Brain and Phenotypic Quantification in Alzheimer's Disease Entorhinal Cortex.. Neuroscience, 372, 289-303. doi:10.1016/j.neuroscience.2017.12.019
  • Zapiec, B., Dieriks, B., Tan, S., Faull, R., Mombaerts, P., & Curtis, M. (2017). A ventral glomerular deficit in Parkinson’s disease revealed by whole olfactory bulb reconstruction. Brain, 140(10), 2722-2736. doi:10.1093/brain/awx208
  • Gardner, B., Dieriks, B. V., Cameron, S., Mendis, L. H., Turner, C., Faull, R. L., & Curtis, M. A. (2017). Metal concentrations and distributions in the human olfactory bulb in Parkinson's disease. Scientific Reports, 7, 1-14. doi:10.1038/s41598-017-10659-6
  • Monzo, H. J., Coppieters, N., Park, T. I., Dieriks, B. V., Faull, R. L., Dragunow, M., & Curtis, M. A. (2017). Insulin promotes cell migration by regulating PSA-NCAM. Experimental Cell Research, 355(1), 26-39. doi:10.1016/j.yexcr.2017.03.029
  • Dieriks, B. V., Park, T. I. -H., Fourie, C., Faull, R. L., Dragunow, M., & Curtis, M. A. (2017). α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients. Scientific Reports, 7. doi:10.1038/srep42984
  • Murray, H. C., Low, V. F., Swanson, M. E. V., Dieriks, B. V., Turner, C., Faull, R. L. M., & Curtis, M. A. (2016). Distribution of PSA-NCAM in normal, Alzheimer’s and Parkinson’s disease human brain. Neuroscience, 330, 359-375. doi:10.1016/j.neuroscience.2016.06.003
  • Beck, M., Rombouts, C., Moreels, M., Aerts, A., Quintens, R., Tabury, K., Dieriks, B.V., . . . Baatout, S. (2014). Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation.. International journal of molecular medicine, 34(4), 1124-1132. doi:10.3892/ijmm.2014.1893
  • Coppieters, N., Dieriks, B. V., Lill, C., Faull, R. L., Curtis, M. A., & Dragunow, M. (2014). Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain. Neurobiology of Aging, 35(6), 1334-1344. doi:10.1016/j.neurobiolaging.2013.11.031
  • Monzo, H. J., Park, T. I., Dieriks, B. V., Jansson, D., Faull, R. L., Dragunow, M., & Curtis, M. A. (2013). Insulin and IGF1 modulate turnover of polysialylated neural cell adhesion molecule (PSA-NCAM) in a process involving specific extracellular matrix components. Journal of Neurochemistry, 126(6), 758-770. doi:10.1111/jnc.12363
  • Dieriks, B. V., Waldvogel, H. J., Monzo, H. J., Faull, R. L., & Curtis, M. A. (2013). GABA(A) receptor characterization and subunit localization in the human sub-ventricular zone.GABAA. Journal of Chemical Neuroanatomy, 52, 58-68. doi:10.1016/j.jchemneu.2013.06.001
  • Dieriks, B. V. (2012). Spatiotemporal behaviour of nuclear Cyclophilin B indicates a role in RNA transcription. International Journal of Molecular Medicine, Fist online, 1031-1038. doi:10.3892/ijmm.2012.937
  • Dieriks, B. V. (2011). Multiplexed profiling of secreted proteins for the detection of potential space biomarkers. Molecular Medicine Reports, 4, 17-23.
  • Dieriks, B. V., De Vos, W., & Baatout, S. (2011). Repeated exposure of human fibroblasts to ionizing radiation reveals an adaptive response that is not mediated by interleukin-6 or TGF-β. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 715(1-2), 19-24. doi:10.1016/j.mrfmmm.2011.07.002
  • Dieriks, B. V., Van Oostveldt, P., & De Vos, H. (2010). Interplanetary space travel and long-term habitation on Mars. Journal of Cosmology, 12, 4113-4120.
  • Dieriks, B. V., De Vos, W., van Neste, L., Joss, G., & Van Oostveldt, P. (2010). High content image cytometry in the context of subnuclear organization. Cytometry Part A, 77, 54-75. doi:10.1002/cyto.a.20807
  • Dieriks, B. V., De Vos, W., Derradji, H., Baatout, S., & Van Oostveldt, P. (2010). Medium-mediated DNA damage response after ionizing radiation is correlated with the increase of specific cytokines in human fibroblasts. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 687(1-2), 40-48. doi:10.1016/j.mrfmmm.2010.01.011
  • Dieriks, B., De Vos, W., Meesen, G., Van Oostveldt, K., De Meyer, T., Ghardi, M., . . . Van Oostveldt, P. (2009). High content analysis of human fibroblast cell cultures after exposure to space radiation. Radiation research, 172(4), 423-436. doi:10.1667/rr1682.1
  • Dieriks, B. V., Verbrugghe, P. L., Wealput, W., Vandesompele, J., & Cuvelier, C. A. (2006). Murine M cells express annexin V specifically. Journal of Pathology, 209(2), 240-249. doi:10.1002/path.1970

Research | Current

Parkinson’s disease (PD) is the second most common neurodegenerative disease characterised by the presence and accumulation of the aberrant protein alpha-synuclein in a brain region called the substantia nigra. Loss of the dopaminergic neurons in this region leads to the motor symptoms that are often associated with PD such as rigidity and slowness of movement. Although PD is described as a movement disorder, there are many non-motor symptoms associated with the disease that become apparent years to decades before the motor symptoms. One of earliest effects of Parkinson's disease is the loss of smell that occurs in 90-95% of the patients. Understanding these early changes is important as it provides a target for halting the disease in an early stage. My research is focussed on figuring out how the human olfactory bulb is affected in Parkinson's disease and how the disease spreads in these early stages. I also have an interest in neurodegenerative diseases such as Alzheimer, Huntington and Motor neuron Disease due to the overlap in disease mechanisms.

 

Areas of expertise

Parkinson's disease, neurodegenerative diseases, tunneling nanotubes, olfactory bulb, Huntington's disease

Selected publications and creative works (Research Outputs)

  • Macapagal, J., Park, T., Joret, M., Rustenhoven, J., Dieriks, B., Faull, R., ... Dragunow, M. (2018). THE POTENTIAL CONTRIBUTION OF PERICYTES TO GLIOBLASTOMA MULTIFORME TUMOUR MICRO-ENVIRONMENT IMMUNOSUPPRESSION VIA DAMPENED EXPRESSION OF ICAM-1, VCAM-1 AND MCP-1. Paper presented at 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA. 14 November - 18 November 2018. NEURO-ONCOLOGY. (pp. 1).
  • Park, T., Kim, B., Macapagal, J., Dieriks, B., Schweder, P., Heppner, P., ... Dragunow, M. (2018). PSA-NCAM IN GLIOBLASTOMA - A NEGATIVE PROGNOSTIC MARKER AND A THERAPEUTIC TARGET?. Paper presented at 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA. 14 November - 18 November 2018. NEURO-ONCOLOGY. (pp. 2).
  • Stevenson, T. J., Dieriks, B. V., Dragunow, M., & Curtis, M. A. (2018). Quantification of non-neuronal cells containing intracellular α-synuclein in the human Parkinson’s disease olfactory bulb. Paper presented at AWCBR 2018, Queenstown, New Zealand. 25 August - 29 August 2018.
    URL: http://hdl.handle.net/2292/45607
    Other University of Auckland co-authors: Taylor Stevenson, Maurice Curtis
  • Dieriks, B. V., Stevenson, T., Murray, H. C., Faull, R. L. M., Dragunow, M., & Curtis, M. A. (2018). Non-neuronal cells enable transmission of α-synuclein in Parkinson’s disease. Paper presented at AWCBR 2018, Queenstown, New Zealand. 25 August - 29 August 2018.
    URL: http://hdl.handle.net/2292/44979
    Other University of Auckland co-authors: Taylor Stevenson, Helen Murray, Richard Faull, Maurice Curtis
  • Murray, H. C., Swanson, M. E. V., Dieriks, B. V., Turner, C., Faull, R. L. M., & Curtis, M. A. (2018). Neurochemical Characterization of PSA-NCAM+ Cells in the Human Brain and Phenotypic Quantification in Alzheimer's Disease Entorhinal Cortex. Neuroscience, 372, 289-303. 10.1016/j.neuroscience.2017.12.019
    URL: http://hdl.handle.net/2292/43018
    Other University of Auckland co-authors: Richard Faull, Helen Murray, Maurice Curtis, Molly Swanson
  • Dieriks, B. V., Dean, J. M., Aronica, E., Waldvogel, H. J., Faull, R. L. M., & Curtis, M. A. (2018). Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone. Developmental neuroscience, 40 (2), 145-161. 10.1159/000487633
    URL: http://hdl.handle.net/2292/44827
    Other University of Auckland co-authors: Richard Faull, Henry Waldvogel, Maurice Curtis, Justin Dean
  • Zapiec, B., Dieriks, B., Tan, S., Faull, R., Mombaerts, P., & Curtis, M. (2017). A ventral glomerular deficit in Parkinson’s disease revealed by whole olfactory bulb reconstruction. Brain, 140 (10), 2722-2736. 10.1093/brain/awx208
    URL: http://hdl.handle.net/2292/42821
    Other University of Auckland co-authors: Maurice Curtis, Richard Faull, Sheryl Tan
  • Dieriks, B. V., Stevenson, T., Dragunow, M., Faull, R. L. M., & Curtis, M. A. (8/9/2017). Non-neuronal uptake and transport of alpha-synuclein in primary human brain cells. Poster presented at SYNUCLEIN 2017 Meeting: 20 years of alpha-synuclein in Parkinson's Disease and related synucleinopathies: From the bedside to the bench and back to the patient, Athens, Greece.
    Other University of Auckland co-authors: Taylor Stevenson, Michael Dragunow, Richard Faull, Maurice Curtis

Identifiers

Contact details

Primary office location

M&HS BUILDING 503 - Bldg 503
Level 5, Room 501
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

Web links