Dr Yongchuan Gu

Biography

Dr Gu obtained BPharmSci in Medicinal Chemistry in 1993 and MSc in Pharmacology in 2002. He was invited to University of Otago as a visiting Research Fellow in 2002 to carry out preclinical development of a mitochondria-targeted antioxidant at School of Pharmacy. He gained experience on GLP operation / documentation at ZenithTechnology Ltd, a NZ-based bioanalytical & pharmacokinetic specialty CRO, where he acted as a Senior Scientist in charge of method development / validations for a variety of drugs. He conferred his PhD from University of Auckland in 2010 and finished postdoc training in Auckland Cancer Society Research Centre where he was responsible for preclinical development for different drug discovery programs targeting tumour hypoxia. His current research interest is developing targeted proteomics technology as a powerful tool to probe potential biomarkers of HAPs with the goal of identifying patients that will be responsive to the therapy. He was recognised with receipt of the 2013 Keith & Meida Hepburn Young Scientist of the Year Award by the Cancer Society Auckland for his contribution to anti-cancer drug development in NZ.

Teaching | Current

Drugs and Society (P111G)
PostGrad course -Pharmaceutical Quality Assurance (P752)
 

Distinctions/Honours

Li Family Cancer Research Fellowship (2016)
AAHA Collaborative Research Grant (2015)
AMRF project grant (2014)
HRC Programme (2014)
Marsden Fund (2013)
Keith & Meida Hepburn Young Scientist of the Year (2013)
NZ-China Scientist Exchange Programme (2013)
Genesis Oncology Research Grant (2011)
Technology for Industry Fellowships (2006)

Committees/Professional groups/Services

American Association for Cancer Research; American Society for Pharmacology and Experimental Therapeutics; American Association of Pharmaceutical Scientists; Auckland Cancer Research Network; Maurice Wilkins Centre

Selected publications and creative works (Research Outputs)

  • Zhu, H., Hu, Y., Zeng, C., Chang, L., Ge, F., Wang, W., ... Ying, M. (2020). The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. Theranostics, 10 (5), 2188-2200. 10.7150/thno.39151
  • Wong, W. W., Jackson, R. K., Liew, L. P., Dickson, B. D., Cheng, G. J., Lipert, B., ... Hay, M. P. (2019). Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361. Biochemical pharmacology, 16910.1016/j.bcp.2019.113641
    URL: http://hdl.handle.net/2292/50047
    Other University of Auckland co-authors: Barbara Lipert, Way Wong, Benjamin Dickson, Francis Hunter, Michael Hay, Lydia Liew
  • Svirskis, D., Behera, S., Naidoo, N., Beachman, J., Raina, T., Zhou, Y., ... Gu, Y. (2019). Stability of vincristine sulfate, doxorubicin hydrochloride and etoposide phosphate admixtures in polyisoprene elastomeric pump supporting transition of the EPOCH regimen to outpatient care. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 25 (4), 831-840. 10.1177/1078155218764285
    Other University of Auckland co-authors: Darren Svirskis
  • Wang, Y., Gu, Y., Fang, K., Mao, K., Dou, J., Fan, H., ... Wang, H. (2018). Lactobacillus acidophilus and Clostridium butyricum ameliorate colitis in murine by strengthening the gut barrier function and decreasing inflammatory factors. Beneficial microbes, 9 (5), 775-787. 10.3920/bm2017.0035
  • Stornetta, A., Deng, K.-C. K., Danielli, S., Liyanage, H. D. S., Sturla, S. J., Wilson, W. R., & Gu, Y. (2018). Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A. Biochemical pharmacology, 154, 64-74. 10.1016/j.bcp.2018.04.004
  • Bonnet, M., Hong, C. R., Wong, W. W., Liew, L. P., Shome, A., Wang, J., ... Anderson, R. F. (2018). Next-generation hypoxic cell radiosensitizers: Nitroimidazole alkylsulfonamides. Journal of Medicinal Chemistry, 61 (3), 1241-1254. 10.1021/acs.jmedchem.7b01678
    URL: http://hdl.handle.net/2292/41805
    Other University of Auckland co-authors: Michael Hay, Lydia Liew, Way Wong, Bob Anderson, Stephen Jamieson, Kevin Hicks, Frederik Pruijn, Ralph Stevenson, Avik Shome, Cho Rong Hong
  • Gu, Y., Chang, T. T.-A., Wang, J., Jaiswal, J. K., Edwards, D., Downes, N. J., ... Hickey, A. J. (2017). Reductive metabolism influences the toxicity and pharmacokinetics of the hypoxia-targeted benzotriazine di-oxide anticancer agent SN30000 in mice. Frontiers in Pharmacology, 8, 1-16. 10.3389/fphar.2017.00531
    URL: http://hdl.handle.net/2292/43982
    Other University of Auckland co-authors: Tony Hickey, Jagdish Jaiswal, Frederik Pruijn, Michael Hay, Kevin Hicks, Courtney Lynch
  • Gu, Y., Deng, K.-C., Liyanage, S., Pruijn, F., & Wilson, W. (2016). Targeted proteomic profiling of enzymes that activate the prodrug PR-104A in human leukaemias. Paper presented at 15th Human Proteome Orgnisation World Congress, Taipei, Taiwan. 18 September - 22 September 2016.
    Other University of Auckland co-authors: Frederik Pruijn

Contact details

Primary office location

M&HS BUILDING 504 - Bldg 504
Level B, Room B01A
85 PARK RD
GRAFTON
AUCKLAND 1023
New Zealand

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